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Table 3 Comparison of power for the main treatment effect with power for interaction test, using the population average model (GEE)

From: Testing for heterogeneity among the components of a binary composite outcome in a clinical trial

  OR1 = 0.65 OR1 = 0.65 OR1 = 0.70 OR1 = 0.70 OR1 = 0.75 OR1 = 0.75
OR2 Treatment Effect Heterogeneity Test Treatment Effect Heterogeneity Test Treatment Effect Heterogeneity Test
0.65 >99.9 5.3 - - - -
0.70 99.9 8.1 99.4 5.0 - -
0.75 99.6 17.9 98.2 8.3 95.7 5.5
0.80 98.2 33.4 95.7 16.7 89.8 8.3
0.85 95.5 51.1 89.5 30.5 81.5 16.0
0.90 90.7 67.8 81.6 44.1 68.7 28.6
0.95 82.2 80.7 70.4 63.5 55.5 43.7
1.00 70.7 89.9 57.8 78.8 41.5 58.9
1.05 57.7 95.0 42.9 86.3 28.2 72.4
1.10 44.6 97.8 30.2 92.8 18.9 82.4
1.15 31.3 99.0 19.6 96.8 11.3 90.5
1.20 21.5 99.7 8.1 98.3 7.2 94.8