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Table 4 Coverage probability of the 95% confidence interval for the revised product-based estimator (ESRR) using a binomial variance

From: Evaluation of exposure-specific risks from two independent samples: A simulation study

Low exposure probability (.05)/Low disease probability in unexposed (.02)

 

RR/ESR

Sample Size

(N1/N2)

1.0/.02

1.5/.03

2.0/.04

2.5/.05

3.0/.06

4.0/.08

5.0/.10

1,000/1,000

66.1

78.1

83.2

87.1

89.6

88.9

90.0

1,000/5,000

98.9

99.3

99.6

99.7

99.9

99.5

99.5

5,000/1,000

54.4

60.6

61.2

62.3

63.5

64.9

65.0

5,000/5,000

90.0

92.8

92.8

93.7

92.4

94.4

94.8

Low exposure probability (.05)/Moderate disease probability in unexposed (.09)

 

RR/ESR

Sample Size

(N1/N2)

1.0/.09

1.5/.14

2.0/.18

2.5/.23

3.0/.27

4.0/.36

5.0/.45

1,000/1,000

90.4

91.6

93.2

92.4

92.2

92.0

91.5

1,000/5,000

99.9

100

100

100

99.9

99.7

99.3

5,000/1,000

62.8

63.8

63.9

63.7

62.1

61.6

62.7

5,000/5,000

93.8

93.4

94.2

93.5

93.7

93.6

91.6

High exposure probability (.20)/Low disease probability in unexposed (.02)

 

RR/ESR

Sample Size

(N1/N2)

1.0/.02

1.5/.03

2.0/.04

2.5/.05

3.0/.06

4.0/.08

5.0/.10

1,000/1,000

89.1

91.2

91.8

92.6

91.5

92.5

93.8

1,000/5,000

99.7

99.1

99.4

99.0

98.0

98.8

98.1

5,000/1,000

63.9

68.0

64.7

69.3

70.7

70.5

71.9

5,000/5,000

92.1

94.0

95.1

94.8

94.3

94.5

93.5

High exposure probability (.20)/Moderate disease probability in unexposed (.09)

 

RR/ESR

Sample Size

(N1/N2)

1.0/.09

1.5/.14

2.0/.18

2.5/.23

3.0/.27

4.0/.36

5.0/.45

1,000/1,000

92.5

93.2

95.1

94.5

92.6

90.7

86.7

1,000/5,000

99.9

99.7

98.9

98.8

98.2

97.3

95.5

5,000/1,000

66.0

68.3

69.7

69.0

64.4

66.6

66.0

5,000/5,000

94.0

94.0

93.2

94.0

91.9

92.0

88.9

  1. N1 is the sample the overall risk is derived from
  2. N2 is the sample the relative risk is derived from
  3. Relative Risk/Exposure-Specific Risk (RR/ESR) values are the hypothesized values
  4. Italics denote coverage probabilities that did not attain 95%