Figure 4

Simulation results for variations on proposed method. The mean, over 1,000 simulations, of the mean time and the error in the mean time for trials with (a) 100 and (b) 500 patients for the proposed method and variations on the proposed method. The population mean time is 10, as indicated by the horizontal lines. 1,000 simulations are sufficiently large that the 95% error bars (not shown) are virtually indistinguishable from the mean/median values in Figures 4, 5 and 6.