Figure 4

RVSOM statistics plotted against study number for the magnesium study. (a) Variance shift estimates, ${\widehat{\omega }}_j^2$. (b) Treatment effect estimates $\widehat{\mu }$. (c) Random effect variance estimates ${\widehat{\tau }}^2$. (d) Likelihood ratio test statistics for a RVSOM for study j, plotted against study number. 95th percentile of the empirical distribution under the null hypothesis shown for the first k order statistics for each test: k = 1 (dotted line), k = 2 (dashed line) and k = 3 (solid line).