Skip to main content

Table 3 Estimates of intervention effects in COMPETE II trial

From: Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study

Model Estimate of
intervention effect
SE 95% CI Variance component
A: Simple linear regression 1.270 0.246 (0.787, 1.753) σ e 2 = 7.712
B: Fixed-effects regression 1.291 0.231 (0.836, 1.745) σ e 2 = 6.682
C: Mixed-effects regression 1.263 0.230 (0.811, 1.714) σ e 2 = 6.678
σ b 2 = 1.069
D: GEE 1.263 0.193 (0.884, 1.641)  
E - 1: centre-level
Fixed-effects model
1.397 0.219 (0.967, 1.826)  
E - 2: centre-level
Random-effects model
1.397 0.219 (0.967, 1.826)  
  1. SE: standard error; CI: confidence interval; σ e 2 : within-centre variance; σ b 2 : between-centre variance; ICC: intraclass (intracentre) correlation