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Table 5 Coverage of the 95% interval estimate of the treatment effect and statistical power of Models A - E in scenarios 1 to 3

From: Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study

  ICC = 0.01 ICC = 0.05 ICC = 0.20
Model Cover.
of CI
Power Cover.
of CI
Power Cover.
of CI
Power
Scenario 1 - balanced design, 45 centres each with 4 subjects
A 0.952 0.901 0.953 0.912 0.973 0.862
B 0.947 0.905 0.945 0.924 0.951 0.899
C 0.947 0.907 0.944 0.924 0.951 0.899
D 0.941 0.911 0.936 0.931 0.933 0.902
E-1 0.286 0.902 0.294 0.920 0.320 0.912
E-2 0.933 0.810 0.921 0.818 0.938 0.821
Scenario 2 - balanced design, 18 centres each with 10 subjects
A 0.955 0.899 0.941 0.903 0.973 0.881
B 0.954 0.906 0.935 0.906 0.954 0.916
C 0.951 0.908 0.935 0.906 0.954 0.916
D 0.929 0.909 0.902 0.919 0.940 0.924
E-1 0.845 0.904 0.835 0.917 0.857 0.924
E-2 0.921 0.868 0.905 0.886 0.938 0.875
Scenario 3 - balanced design, 6 centres each with 30 subjects
A 0.953 0.905 0.949 0.901 0.966 0.888
B 0.948 0.907 0.947 0.906 0.952 0.918
C 0.948 0.907 0.946 0.906 0.952 0.918
D 0.860 0.915 0.854 0.931 0.867 0.929
E-1 0.939 0.918 0.931 0.910 0.926 0.927
E-2 0.952 0.867 0.949 0.846 0.953 0.880
  1. Cover. of CI: coverage proportion of 95% confidence interval; ICC: intraclass (intracentre) correlation