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Table 5 Coverage of the 95% interval estimate of the treatment effect and statistical power of Models A - E in scenarios 1 to 3

From: Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study

 

ICC = 0.01

ICC = 0.05

ICC = 0.20

Model

Cover.

of CI

Power

Cover.

of CI

Power

Cover.

of CI

Power

Scenario 1 - balanced design, 45 centres each with 4 subjects

A

0.952

0.901

0.953

0.912

0.973

0.862

B

0.947

0.905

0.945

0.924

0.951

0.899

C

0.947

0.907

0.944

0.924

0.951

0.899

D

0.941

0.911

0.936

0.931

0.933

0.902

E-1

0.286

0.902

0.294

0.920

0.320

0.912

E-2

0.933

0.810

0.921

0.818

0.938

0.821

Scenario 2 - balanced design, 18 centres each with 10 subjects

A

0.955

0.899

0.941

0.903

0.973

0.881

B

0.954

0.906

0.935

0.906

0.954

0.916

C

0.951

0.908

0.935

0.906

0.954

0.916

D

0.929

0.909

0.902

0.919

0.940

0.924

E-1

0.845

0.904

0.835

0.917

0.857

0.924

E-2

0.921

0.868

0.905

0.886

0.938

0.875

Scenario 3 - balanced design, 6 centres each with 30 subjects

A

0.953

0.905

0.949

0.901

0.966

0.888

B

0.948

0.907

0.947

0.906

0.952

0.918

C

0.948

0.907

0.946

0.906

0.952

0.918

D

0.860

0.915

0.854

0.931

0.867

0.929

E-1

0.939

0.918

0.931

0.910

0.926

0.927

E-2

0.952

0.867

0.949

0.846

0.953

0.880

  1. Cover. of CI: coverage proportion of 95% confidence interval; ICC: intraclass (intracentre) correlation