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Table 7 Coverage of the 95% interval estimate of the treatment effect and statistical power of Models A - E in scenarios 4 to 6

From: Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study

  ICC = 0.01 ICC = 0.05 ICC = 0.20
Model Cover.
of CI
Power Cover.
of CI
Power Cover.
of CI
Power
Scenario 4 - chance imbalance, 45 centres each with 4 subjects
A 0.954 0.910 0.949 0.918 0.942 0.845
B 0.966 0.846 0.946 0.822 0.931 0.810
C 0.954 0.912 0.945 0.917 0.934 0.870
D 0.948 0.924 0.934 0.926 0.934 0.878
E-1 0.411 0.782 0.417 0.793 0.424 0.745
E-2 0.897 0.468 0.900 0.501 0.887 0.468
Scenario 5 - chance imbalance, 18 centres each with 10 subjects
A 0.954 0.898 0.949 0.900 0.942 0.843
B 0.946 0.874 0.959 0.891 0.937 0.891
C 0.952 0.898 0.951 0.904 0.939 0.895
D 0.922 0.916 0.932 0.911 0.910 0.900
E-1 0.776 0.868 0.794 0.890 0.791 0.895
E-2 0.905 0.810 0.918 0.834 0.918 0.839
Scenario 6 - chance imbalance, 6 centres each with 30 subjects
A 0.950 0.897 0.953 0.905 0.961 0.860
B 0.949 0.892 0.954 0.907 0.961 0.916
C 0.950 0.897 0.952 0.905 0.959 0.910
D 0.856 0.911 0.879 0.918 0.874 0.908
E-1 0.922 0.904 0.931 0.921 0.931 0.913
E-2 0.944 0.831 0.951 0.867 0.955 0.857
  1. Cover. of CI: coverage proportion of 95% confidence interval; ICC: intraclass (intracentre) correlation