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Archived Comments for: Assessing methods for dealing with treatment switching in randomised controlled trials: a simulation study

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  1. Law & Kaldor method

    Ian R White, MRC Biostatistics Unit

    25 March 2011

    This article quotes me as saying (in reference 13) that the Law & Kaldor method is likely to be biased towards the null. But in fact reference 13 illustrates a far worse situation: data were simulated with no treatment effect, yet the Law & Kaldor method estimated an "adjusted" hazard ratio of 1.48 (95% CI 1.44 to 1.52). By contrast, methods based on a structural model have the highly desirable property of being unbiased under the null.

    Competing interests