Scenario Number | Treatment effect (HR) | % with 'good' Prognosis | 'Good' prognosis Survival | Crossover probabilities ('good' and 'poor' prognosis) | Table Number | ||||
---|---|---|---|---|---|---|---|---|---|
 | 0.9 | 0.7 | 30% | 75% | ×1.2 | ×3 | 10% and 25% | 50% and 75% |  |
1 | √ |  | √ |  | √ |  | √ |  | 3 |
2 |  | √ | √ |  | √ |  | √ |  | 3 |
3 | √ |  |  | √ | √ |  | √ |  | Additional file 1 |
4 |  | √ |  | √ | √ |  | √ |  | Additional file 1 |
5 | √ |  | √ |  | √ |  |  | √ | 4 |
6 |  | √ | √ |  | √ |  |  | √ | 4 |
7 | √ |  |  | √ | √ |  |  | √ | Additional file 2 |
8 |  | √ |  | √ | √ |  |  | √ | Additional file 2 |
9 | √ |  | √ |  |  | √ | √ |  | 5 |
10 |  | √ | √ |  |  | √ | √ |  | 5 |
11 | √ |  |  | √ |  | √ | √ |  | Additional file 3 |
12 |  | √ |  | √ |  | √ | √ |  | Additional file 3 |
13 | √ |  | √ |  |  | √ |  | √ | 6 |
14 |  | √ | √ |  |  | √ |  | √ | 6 |
15 | √ |  |  | √ |  | √ |  | √ | Additional file 4 |
16 |  | √ |  | √ |  | √ |  | √ | Additional file 4 |