|
Hazard ratio methods
| | | | | | | | | |
|
ITT
|
0.9364
|
0.0909
|
0.0909
|
0.7741
|
1.1328
|
0.0364
|
0.0096
|
93.6
|
100.0
|
|
PP - Exclude switchers
|
0.9204
|
0.1275
|
0.1278
|
0.7016
|
1.2074
|
0.0204
|
0.0167
|
96.0
|
100.0
|
|
PP - Censor at switch
|
2.1663
|
0.3018
|
0.2975
|
1.6488
|
2.8466
|
1.2663
|
1.6921
|
0.0
|
100.0
|
|
Time-dependent covariate
|
3.0639
|
0.4065
|
0.4054
|
2.3625
|
3.9740
|
2.1639
|
4.8466
|
0.0
|
100.0
|
|
Law and Kaldor
|
0.9396
|
0.1168
|
0.1144
|
0.7364
|
1.1987
|
0.0396
|
0.0147
|
94.2
|
100.0
|
|
Loeys and Goethebeur
|
0.8435
|
-
|
0.2725
|
0.4578
|
1.8486
|
-0.0565
|
0.0774
|
92.8
|
99.9
|
0.9 & 1.23
|
AFT methods
| | | | | | | | | |
|
ITT
|
1.1732
|
0.2280
|
0.2311
|
0.8018
|
1.7173
|
-0.0613
|
0.0572
|
93.2
|
100.0
|
|
PP - Exclude switchers
|
1.2492
|
0.1275
|
0.3479
|
0.7276
|
2.1475
|
0.0146
|
0.1212
|
95.9
|
100.0
|
|
PP - Censor at switch
|
0.2373
|
0.0665
|
0.0663
|
0.1371
|
0.4115
|
-0.9973
|
0.9989
|
0.0
|
100.0
|
|
Robins and Tsiatis - Logrank
|
1.2882
|
-
|
0.3862
|
0.6906
|
2.2552
|
0.0536
|
0.1521
|
93.8
|
100.0
|
|
Robins and Tsiatis - Cox
|
1.2855
|
-
|
0.3874
|
0.6868
|
2.2531
|
0.0509
|
0.1527
|
93.9
|
96.3
|
|
Robins and Tsiatis - Exponential
|
1.3036
|
-
|
0.3693
|
0.9172
|
1.9617
|
0.0691
|
0.1412
|
83.6
|
100.0
|
|
Robins and Tsiatis - Weibull
|
1.2879
|
-
|
0.3857
|
0.6988
|
2.2550
|
0.0534
|
0.1516
|
94.5
|
100.0
|
|
Branson and Whitehead
|
1.2841
|
0.2497
|
0.3619
|
0.8772
|
1.8802
|
0.0495
|
0.1334
|
83.7
|
100.0
|
|
Walker et al
|
2.1037
|
0.7802
|
0.7791
|
1.0276
|
4.4146
|
0.8692
|
1.3624
|
70.0
|
99.8
|
|
Hazard ratio methods
| | | | | | | | | |
|
ITT
|
0.8073
|
0.0812
|
0.0814
|
0.6629
|
0.9833
|
0.1073
|
0.0181
|
71.5
|
100.0
|
|
PP - Exclude switchers
|
0.7179
|
0.1009
|
0.1019
|
0.5451
|
0.9457
|
0.0179
|
0.0107
|
94.8
|
100.0
|
|
PP - Censor at switch
|
1.6825
|
0.2388
|
0.2454
|
1.2740
|
2.2223
|
0.9825
|
1.0256
|
0.0
|
100.0
|
|
Time-dependent covariate
|
2.4211
|
0.3257
|
0.3396
|
1.8602
|
3.1516
|
1.7211
|
3.0776
|
0.0
|
100.0
|
|
Law and Kaldor
|
0.8110
|
0.1064
|
0.1046
|
0.6271
|
1.0488
|
0.1110
|
0.0233
|
81.2
|
100.0
|
|
Loeys and Goethebeur
|
0.5248
|
-
|
0.1728
|
0.2544
|
1.0233
|
-0.1752
|
0.0606
|
83.8
|
99.0
|
0.7 & 2.04
|
AFT methods
| | | | | | | | | |
|
ITT
|
1.5845
|
0.3208
|
0.3294
|
1.0657
|
2.3569
|
-0.4563
|
0.3167
|
72.2
|
100.0
|
|
PP - Exclude switchers
|
2.0610
|
0.1009
|
0.6062
|
1.1886
|
3.5793
|
0.0202
|
0.3679
|
94.4
|
100.0
|
|
PP - Censor at switch
|
0.3894
|
0.1088
|
0.1126
|
0.2254
|
0.6742
|
-1.6514
|
2.7398
|
0.0
|
100.0
|
|
Robins and Tsiatis - Logrank
|
2.1120
|
-
|
0.6624
|
1.1204
|
3.8159
|
0.0712
|
0.4439
|
94.8
|
100.0
|
|
Robins and Tsiatis - Cox
|
2.1062
|
-
|
0.6612
|
1.1095
|
3.8198
|
0.0654
|
0.4415
|
95.1
|
92.6
|
|
Robins and Tsiatis - Exponential
|
2.1121
|
-
|
0.6636
|
1.3323
|
3.3923
|
0.0713
|
0.4455
|
87.4
|
100.0
|
|
Robins and Tsiatis - Weibull
|
2.1128
|
-
|
0.6631
|
1.1249
|
3.8301
|
0.0719
|
0.4449
|
94.9
|
100.0
|
|
Branson and Whitehead
|
2.0536
|
0.4177
|
0.6096
|
1.3787
|
3.0601
|
0.0127
|
0.3718
|
83.0
|
100.0
|
|
Walker et al
|
3.6581
|
1.3293
|
1.2498
|
1.8098
|
7.5537
|
1.6172
|
4.1774
|
63.9
|
98.0
|