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Table 4 Functions of parameter estimates for different fractional polynomials

From: Network meta-analysis of survival data with fractional polynomials

 

Fixed effects model, first order fractional polynomial

Fixed effects model, second order fractional polynomial

Random effects model (d0), second order fractional polynomial

 

Median of posterior distribution

95% Credible Interval

Median of posterior distribution

95% Credible Interval

Median of posterior distribution

95% Credible Interval

Docetaxel *

      

   β0A

-2.422

(-2.502; -2.348)

-2.689

(-2.882; -2.476)

-2.694

(-2.895; -2.513)

   β1A

-2.174

(-2.988; -1.401)

-1.224

(-2.324; -0.198)

-1.193

(-2.267; -0.206)

   β2A

  

0.013

(0.004; 0.022)

0.014

(0.006; 0.022)

Gefitinib

      

   β0B (β0A +d 0AB )

-2.425

(-2.515; -2.325)

-2.531

(-2.776; -2.322)

-2.550

(-2.777; -2.273)

   β1B (β1A +d 1AB )

-1.540

(-2.527; -0.631)

-1.227

(-2.407; 0.082)

-1.124

(-2.433; 0.010)

   β2B (β2A +d 2AB )

  

0.007

(-0.002; 0.018)

0.008

(-0.002; 0.016)

BSC

      

   β 0C (β0A +d 0AC )

-1.652

(-1.818; -1.461)

-1.015

(-1.600; -0.480)

-1.041

(-1.554; -0.462)

   β1C (β1A +d 1AC )

-4.681

(-6.564; -3.010)

-7.082

(-9.677; -4.320)

-7.032

(-9.700; -4.622)

   β2C (β2A +d 2AC )

  

-0.040

(-0.071; -0.008)

-0.039

(-0.069; -0.010)

Pemetrexed

      

   β0D (β0 A +d 0AD )

-2.402

(-2.616; -2.188)

-2.548

(-3.101; -1.954)

-2.552

(-3.093; -1.978)

   β1D (β1A +d 1AD )

-3.169

(-5.445; -0.673)

-2.583

(-5.634; 0.308)

-2.561

(-5.329; 0.167)

   β2D (β2A +d 2AD )

  

0.009

(-0.018; 0.033)

0.009

(-0.014; 0.028)

Expected survival (in months)

      

   docetaxel

12.5

(11.9; 13.3)

13.0

(12.2; 13.8)

13.0

(12.2; 13.9)

   gefitinib

12.1

(11.3; 13.0)

12.2

(11.3; 13.2)

12.2

(10.6; 14.0)

   BSC

7.2

(6.5; 8.1)

6.2

(5.1; 7.6)

6.2

(4.8; 7.9)

   pemetrexed

12.7

(10.9; 14.7)

12.7

(10.5; 15.0)

12.9

(9.5; 17.4)

Difference in expected survival (in months)

      

   gefitinib vs docetaxel

-0.4

(-1.4; 0.6)

-0.8

(-1.9; 0.3)

-0.8

(-2.6; 1.1)

   BSC vs docetaxel

-5.3

(-6.2; -4.3)

-6.8

(-8.0; -5.4)

-6.8

(-8.4; -5.0)

   pemetrexed vs docetaxel

0.1

(-1.8; 2.2)

-0.3

(-2.5; 2.0)

-0.2

(-3.6; 4.4)

   BSC vs gefitinib

-4.9

(-6.0; -3.8)

-6.0

(-7.4; -4.5)

-6.0

(-8.1; -3.9)

   pemetrexed vs gefitinib

0.5

(-1.6; 2.8)

0.4

(-2.0; 3.0)

0.6

(-3.2; 5.3)

   pemetrexed vs. BSC

5.4

(3.4; 7.6)

6.4

(3.9; 9.1)

6.7

(3.0; 11.4)

  1. * (calculated as average from docetaxel study specific estimates: μ0, μ1, μ2)