Table 2 Effect of aggressive antihypertensive treatment on INVEST primary outcome: Estimates from a marginal structural Cox model and a standard Cox model
| Â | Hazard Ratio | 95% Confidence Interval |
|---|---|---|
Primary Analysis | ||
Conventional treatment (≤ 2 antihypertensive drugs) | 1.0 |  |
Aggressive treatment (≥3 antihypertensive drugs) |  |  |
Marginal structural Cox model | 0.81 | 0.71-0.92 |
Standard Cox model | 0.96 | 0.87-1.07 |
Sensitivity Analysis 1 | ||
Conventional treatment (≤ 1 antihypertensive drugs) | 1.0 |  |
Aggressive treatment (≥2 antihypertensive drugs) |  |  |
Marginal structural Cox model | 0.83 | 0.64-1.06 |
Standard Cox model | 0.89 | 0.70-1.13 |
Sensitivity Analysis 2 | ||
Conventional treatment (≤3 antihypertensive drugs) | 1.0 |  |
Aggressive treatment (≥4 antihypertensive drugs) |  |  |
Marginal structural Cox model | 0.79 | 0.71-0.89 |
Standard Cox model | 0.98 | 0.90-1.07 |