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Table 3 Difference in expected survival (in months) between interventions as obtained with random effects network meta-analysis model with and without treatment-by-covariate interaction

From: Meta-regression models to address heterogeneity and inconsistency in network meta-analysis of survival outcomes

  Random effects model without covariate interaction (model 1) Random effects model with treatment specific covariate interaction (model 2) Random effects model with constant treatment-by-covariate interaction (model 3)
  Median of posterior distribution 95% Credible Interval Median of posterior distribution 95% Credible Interval Median of posterior distribution 95% Credible Interval
DTIC + IFN vs. DTIC −1.12 (−4.20; 3.49) −2.46 (−5.72; 1.91) −1.90 (−5.10; 2.22)
DTIC + non-IFN vs. DTIC 3.63 (−1.72; 10.75) 3.77 (−1.04; 10.72) 3.21 (−2.39; 9.65)
non-DTIC vs. DTIC 2.66 (−2.38; 13.49) 1.16 (−7.51; 25.76) 6.60 (−0.78; 21.39)
DTIC + non-IFN vs. DTIC + IFN 4.71 (−1.38; 11.37) 6.26 (0.26; 13.29) 5.13 (−1.15; 11.50)
non-DTIC vs. DTIC + IFN 3.81 (−2.40; 14.11) 3.46 (−6.00; 27.88) 8.48 (−0.65; 24.00)
non-DTIC vs. DTIC + non-IFN −0.84 (−9.15; 10.3) −2.79 (−13.90; 22.17) 3.27 (−6.72; 20.74)