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Table 1 Estimates of diagnostic accuracy of the D-dimer test and the calf-difference test in the source population for different values of the prevalence of deep venous thrombosis (DVT)

From: Comparison of approaches to estimate confidence intervals of post-test probabilities of diagnostic test results in a nested case-control study

Prevalence of DVT

PPV*

NPV*

Sensitivity

Specificity

DOR

Positive test result (%)

D-dimer test (dichotomous)

0.05

0.07

0.99

0.96

0.32

10.7

69

0.1

0.14

0.99

0.97

0.33

9.2

70

0.2

0.26

0.97

0.96

0.33

11.9

73

Calf-difference test (dichotomous)

0.05

0.09

0.98

0.69

0.65

4.0

37

0.1

0.17

0.95

0.68

0.64

3.1

39

0.2

0.32

0.89

0.67

0.65

3.8

41

  1. * Estimates of PPV and NPV obtained with the weighted formula, with Mercaldo’s approach and with weighted logistic regression were the same
  2. (PPV = positive predictive value; NPV = negative predictive value, DOR=Diagnostic Odds Ratio).