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Table 1 Estimates of diagnostic accuracy of the D-dimer test and the calf-difference test in the source population for different values of the prevalence of deep venous thrombosis (DVT)

From: Comparison of approaches to estimate confidence intervals of post-test probabilities of diagnostic test results in a nested case-control study

Prevalence of DVT PPV* NPV* Sensitivity Specificity DOR Positive test result (%)
D-dimer test (dichotomous)
0.05 0.07 0.99 0.96 0.32 10.7 69
0.1 0.14 0.99 0.97 0.33 9.2 70
0.2 0.26 0.97 0.96 0.33 11.9 73
Calf-difference test (dichotomous)
0.05 0.09 0.98 0.69 0.65 4.0 37
0.1 0.17 0.95 0.68 0.64 3.1 39
0.2 0.32 0.89 0.67 0.65 3.8 41
  1. * Estimates of PPV and NPV obtained with the weighted formula, with Mercaldo’s approach and with weighted logistic regression were the same
  2. (PPV = positive predictive value; NPV = negative predictive value, DOR=Diagnostic Odds Ratio).