From: The use of continuous data versus binary data in MTC models: A case study in rheumatoid arthritis
Trial | Arm | N | ΔHAQ(SD) | ACR20 | ACR50 | ACR70 | HA Q base |
---|---|---|---|---|---|---|---|
Weinblatt et al. [31] | P+ | 62 | 0.27 (0.6) | 9 | 5 | 3 | 1.64 |
 | Ada+ | 69 | 0.54 (0.6) | 33 | 22 | 7 | 1.52 |
 | Ada+ | 67 | 0.62 (0.6) | 45 | 37 | 18 | 1.55 |
 | Ada+ | 73 | 0.59 (0.5) | 48 | 31 | 14 | 1.55 |
Keystone et al. [32] | P+ | 200 | 0.24 (0.5) | 59 | 19 | 5 | 1.45 |
 | Ada+ | 207 | 0.56 (0.5) | 131 | 81 | 43 | 1.44 |
 | Ada+ | 212 | 0.60 (0.5) | 129 | 87 | 37 | 1.48 |
Van de Putte et al. [33] | P | 110 | 0.07 (0.5) | 21 | 9 | 2 | 1.88 |
 | Ada | 112 | 0.39 (0.6) | 44 | 23 | 11 | 1.88 |
 | Ada | 106 | 0.29 (0.6) | 38 | 20 | 9 | 1.88 |
 | Ada | 103 | 0.49 (0.5) | 55 | 36 | 19 | 1.84 |
 | Ada | 113 | 0.38 (0.6) | 52 | 25 | 14 | 1.83 |
Miyasaka [34] | P | 87 | -0.1 (0.6) | 12 | 5 | 1 | 1.39 |
 | Ada | 87 | 0.2 (0.5) | 25 | 14 | 9 | 1.57 |
 | Ada | 91 | 0.2 (0.6) | 40 | 22 | 11 | 1.64 |
 | Ada | 87 | 0.4 (0.6) | 44 | 28 | 13 | 1.77 |
Kim at el. [35] | P+ | 63 | 0.2 (0.5) | 23 | 9 | 5 | 1.3 |
 | Ada+ | 65 | 0.5 (0.6) | 40 | 28 | 14 | 1.4 |
Maini et al. [36] | P+ | 88 | 0.3 (0.5)†| 18 | 7 | 0 | 1.8 |
 | Inf+ | 86 | 0.3 (0.5)†| 45 | 22 | 7 | 1.8 |
 | Inf+ | 86 | 0.5 (0.5)†| 47 | 25 | 9 | 1.8 |
 | Inf+ | 87 | 0.5 (0.6)†| 51 | 26 | 15 | 1.8 |
 | Inf+ | 81 | 0.4 (0.5)†| 49 | 21 | 9 | 1.5 |
Westhoven et al.[37] | P+ | 363 | - | 87 | 33 | 16 | 1.5 |
 | Inf+ | 360 | - | 199 | 110 | 48 | 1.5 |
 | Inf+ | 361 | - | 205 | 119 | 54 | 1.5 |
Zhang et al. [38] | P+ | 86 | 0.45 (-) | 42 | 22 | 12 | 1.6 |
 | Inf+ | 87 | 0.76 (-) | 66 | 38 | 20 | 1.6 |
Schiff et al. [39] | P+ | 110 | - | 49 | 22 | 10 | 1.8 |
 | Inf+ | 165 | - | 98 | 61 | 40 | 1.7 |
Moreland et al. [40] | P | 80 | 0.03 (-) | 9 | 4 | 1 | 1.7 |
 | Eta | 76 | 0.58 (-) | 39 | 18 | 7 | 1.7 |
 | Eta | 78 | 0.62 (-) | 46 | 31 | 12 | 1.6 |
Weinblatt et al. [41] | P+ | 30 | 0.4 (-) | 8 | 1 | 0 | 1.5 |
 | Eta+ | 59 | 0.7 (-) | 42 | 23 | 9 | 1.5 |
Keystone et al. [42] | P+ | 133 | 0.13red* (0.4)‡ | 37 | 18 | 7 | 1.25* |
 | Gol | 133 | 0.13* (0.7)‡ | 47 | 26 | 15 | 1.38* |
 | Gol+ | 89 | 0.38* (0.5)‡ | 53 | 33 | 18 | 1.38* |
 | Gol+ | 89 | 0.5* (0.5)‡ | 53 | 29 | 16 | 1.38* |
Kay et al. [43] | P+ | 35 | - | 13 | 2 | 0 | 1.3 |
 | Gol+ | 35 | - | 21 | 13 | 3 | 1.7 |
 | Gol+ | 34 | - | 19 | 10 | 6 | 1.8 |
Keystone et al. [44] | P+ | 199 | 0.18 (-) | 27 | 15 | 6 | 1.7 |
 | Cert+ | 393 | 0.60 (-) | 231 | 146 | 84 | 1.7 |
 | Cert+ | 390 | 0.63 (-) | 237 | 156 | 79 | 1.7 |
Smolen et al. [45] | P+ | 127 | 0.14 (0.5) | 11 | 4 | 1 | 1.6 |
 | Cert+ | 246 | 0.5 (0.5) | 141 | 80 | 39 | 1.6 |
 | Cert+ | 246 | 0.5 (0.5) | 142 | 81 | 26 | 1.6 |
Fleischmann et al. [46] | P | 109 | -0.07 (0.4)†| 10 | 4 | 0 | 1.6 |
 | Cert | 111 | 0.39 (0.7)†| 51 | 25 | 9 | 1.4 |