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Table 9 One-stage IPD meta-analyses investigating a non-proportional treatment effect

From: Individual patient data meta-analysis of survival data using Poisson regression models

Framework

Covariate

Poisson (1)

Poisson (0.5)

Poisson (0.25)

  

Hazard Ratio

95% CI

Hazard Ratio

95% CI

Hazard Ratio

95% CI

Classical

Treatment when t < 1, exp ( β ^ 1 )

0.657

0.515

0.839

0.657

0.515

0.838

0.657

0.515

0.838

 

Treatment when t ≥ 1, exp ( β ^ 1 + ϕ ^ )

0.935

0.837

1.045

0.936

0.838

1.045

0.936

0.838

1.045

Bayesian

Treatment when t < 1, exp ( β ^ 1 )

0.657

0.521

0.839

0.656

0.508

0.837

0.657

0.521

0.845

 

Treatment when t ≥ 1, exp ( β ^ 1 + ϕ ^ )

0.934

0.833

1.049

0.936

0.841

1.045

0.935

0.835

1.042