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Table 1 Impact of sample size. Based on 1000 simulated datasets with moderate effect size (0.3) equally distributed between direct and indirect effects. Impact of sample size on model performance in evaluating the total effect of the repeated independent variable on the repeated outcome.

From: Non-linear mixed models in the analysis of mediated longitudinal data with binary outcomes

Simulated Data SEM Unscaled NLMM Scaled NLMM
Sample Size Bias (%) Coverage (%) Power (%) Bias (%) Coverage (%) Power (%) Bias (%) Coverage (%) Power (%)
Logit Link Results
200 1.3 95 35 -2.3 95 34 -0.09 95 35
300 2.3 96 49 -0.8 96 47 1.4 96 48
400 -0.8 95 57 -4.1 95 56 -1.9 95 56
500 0.2 94 68 -2.8 95 68 -0.6 95 68
600 -0.6 94 77 -3.8 94 77 -1.6 94 77
700 0.1 94 83 -3.0 95 83 -0.8 94 84
Probit Link Results
100 51.5 97 20 -4.7 94 31 2.1 94 30
200 20.4 96 42 -4.3 94 53 2.7 94 54
300 11.4 95 57 -7.1 94 72 -0.2 95 72
400 8.3 93 69 -7.9 94 80 -1.2 94 80
500 8.8 95 79 -6.7 93 88 0.2 94 88
600 7.5 94 87 -7.0 93 93 -0.2 94 94
1000 7.5 94 87 -8.8 92 99 -2.1 94 99