Three independent frailties for transitions 01, 02 and 03 | 01 (VAP) | 02 (death) | 03 (discharge) | |||
---|---|---|---|---|---|---|
exp(β) | 95%CI | exp(β) | 95%CI | exp(β) | 95%CI | |
Sex (men=1) | 1.51 | (1.23-1.87) | - | - | 0.85 | (0.78-0.94) |
Age ≥ 62 | - | - | - | - | 0.95 | (0.86-1.05) |
33 < SAPSII ≤ 45 | - | - | 1.62 | (1.03-2.54) | 0.66 | (0.58-0.75) |
45 < SAPSII ≤ 58 | - | - | 2.70 | (1.75-4.14) | 0.56 | (0.49-0.64) |
58 < SAPSII | - | - | 4.83 | (3.18-7.35) | 0.40 | (0.34-0.47) |
Type of Admission : | ||||||
Elective surgery | 1 | - | - | 1 | ||
Emergency surgery | 0.58 | (0.41-0.83) | - | - | 1.04 | (0.90-1.20) |
Medicine | 0.89 | (0.66-1.20) | - | - | 0.96 | (0.82-1.12) |
Chronic diseases | - | - | 1.37 | (1.14-1.66) | 0.84 | (0.76-0.92) |
Diabetes | 1.48 | (1.10-2.00) | 1.30 | (0.97-1.76) | - | - |
Diagnostic or symptoms on ICU admission: | ||||||
ARDS | 1.71 | (1.16-2.54) | - | - | - | - |
Trauma | 2.52 | (1.12-5.67) | - | - | - | - |
Coma | 1.23 | (0.95-1.60) | 2.90 | (1.99-4.22) | 1.06 | (0.91-1.25) |
Shock | 1.21 | (0.96-1.53) | 2.12 | (1.47-3.06) | 0.73 | (0.63-0.84) |
Acute respiratory failure | - | - | 1.79 | (1.22-2.62) | 0.65 | (0.56-0.75) |
Use in the first 24 h of ICU admission : | ||||||
Antimicrobials | 0.61 | (0.50-0.75) | 0.66 | (0.54-0.81) | 0.86 | (0.77-0.95) |
Inotropes | - | - | - | - | 0.74 | (0.67-0.82) |
Enteral nutrition | 1.21 | (0.97-1.50) | 0.76 | (0.60-0.95) | 0.62 | (0.55-0.71) |
Parenteral nutrition | - | - | - | - | 1.00 | (0.87-1.14) |
Variance of the frailty γ (SE) | 0.19(0.11) | 0.09(0.06) | 0.15(0.07) | |||
Two independent frailties for transitions 12 and 13 | 12 (death with VAP) | 13 (discharge with VAP) | ||||
exp(β) | 95%CI | exp(β) | 95%CI | |||
Age ≥ 62 | - | - | 0.84 | (0.66-1.07) | ||
33 < SAPSII ≤ 45 | 2.13 | (1.05-4.31) | - | - | ||
45 < SAPSII ≤ 58 | 2.60 | (1.27-5.31) | - | - | ||
58 < SAPSII | 4.81 | (2.38-9.72) | - | - | ||
Parenteral nutrition | - | 0.70 | (0.51-0.97) | |||
Variance of the frailty γ (SE) | 0.04(0.06) | 0.11(0.08) | ||||
A joint subject-specific frailtyterm for transitions 12 and 13 | 12 (death with VAP) | 13 (discharge with VAP) | ||||
exp( β ) | 95%CI | exp( β ) | 95%CI | |||
Age ≥ 62 | - | - | 0.78 | (0.61-0.98) | ||
33 < SAPSII ≤ 45 | 2.22 | (0.99-4.97) | - | - | ||
45 < SAPSII ≤ 58 | 2.65 | (1.17-6.01) | - | - | ||
58 < SAPSII | 5.19 | (2.31-11.65) | - | - | ||
Parenteral nutrition | - | 0.67 | (0.49-0.90) | |||
Common frailty variance η (SE) | 0.77 (0.13) | |||||
Power coefficient ζ (from η ζ) | -0.16 (0.29) |