Time course of log
HCV RNA after treatment initiation for one simulated dataset with one design (N = 30 patients per PI and n = 7 viral load measurements). A: assuming ϵ = 0.999; B1: assuming ϵ = 0.998; B2: assuming ϵ = 0.995; B3: assuming ϵ = 0.990. In bold, the mean curves predicted by the mean parameters of the model. LOD: limit of detection = log10(12) ≈ 1.08 log10 UI/mL; % < LOD: percentage of patients bellow the LOD at day 3, 7 and 14 estimated from 500 simulated datasets. The mean 14 days log drop were 6.56 log10 IU/mL with ϵ = 0.999, 6.25 log10 IU/mL with ϵ = 0.998, 5.85 log10 IU/mL with ϵ = 0.995 and 5.52 log10 IU/mL with ϵ = 0.990.