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Figure 2 | BMC Medical Research Methodology

Figure 2

From: Clinical trial simulation to evaluate power to compare the antiviral effectiveness of two hepatitis C protease inhibitors using nonlinear mixed effect models: a viral kinetic approach

Figure 2

Boxplot of the relative estimation errors (REE) of the estimated parameters evaluated from 500 simulated datasets. Parameters were simulated assuming ϵA = 0.999, a limit of detection (“ML data”) and ϵB = 0.990 (β = 2.3), with N = 30 patients per PI and with n = 7 viral load (VL) measurements (in white) or n = 5 VL (sparse initial design in gray). On the left: fixed effects and on the right: inter-individual variances (ω²) and residual error (σ).

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