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Table 1 Value, distribution and inter-individual standard deviation of population parameters from data with patients treated by monotherapy of PI-A [7]

From: Clinical trial simulation to evaluate power to compare the antiviral effectiveness of two hepatitis C protease inhibitors using nonlinear mixed effect models: a viral kinetic approach

 

V 0 (IU/mL)

c(day-1)

δ(day-1)

ϵ

σ (log10IU/mL)

Fixed effect

2.68 106

13.4

0.58

0.999

0.19

Transformation

lognormal

lognormal

lognormal

logistic-normal

-

Inter-individual standard deviation (ω)

1.09

0.25

0.25

0.61

-

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BMC Medical Research Methodology

ISSN: 1471-2288

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