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Table 2 Relative bias (RB) (%) and relative root mean square error (RRMSE) (%) of the estimated parameters evaluated from 500 simulated datasets

From: Clinical trial simulation to evaluate power to compare the antiviral effectiveness of two hepatitis C protease inhibitors using nonlinear mixed effect models: a viral kinetic approach

 

All data (n = 7 VL)

ML (n = 7 VL)

ML (n = 5 VL)

 

RB (%)

RRMSE (%)

RB (%)

RRMSE (%)

RB (%)

RRMSE (%)

log10(V 0 ) (IU/mL)

0.1

1.0

0.2

1.0

0.1

1.0

c (day-1)

1.0

4.3

0.6

4.1

34.1

78.8

δ (day-1)

0.2

3.2

0.8

3.7

0.6

3.7

-log10(1-ϵ)

0.1

3.2

0.4

3.1

0.3

3.6

β

0.4

8.5

−0.5

8.5

0.4

9.9

ω 2 vo

−0.4

18.9

−1.0

19.0

−0.5

19.3

ω 2 c

−4.6

31.5

−10.9

32.9

236.6

358.3

ω 2 δ

−3.0

19.8

−2.3

24.5

−2.4

24.9

ω 2 ϵ

−2.6

32.2

−4.5

32.0

−9.9

36.3

σ

−0.03

5.3

−0.7

6.2

−1.3

8.0

  1. Parameters were simulated with N = 30 patients per group assuming ϵ A = 0.999 and ϵ B = 0.990, no limit of detection (“All data”) or a limit of detection at 12 IU/mL (“ML”), and with n = 7 or 5 viral load (VL) measurements per patient.