Skip to main content

Advertisement

Table 2 Relative bias (RB) (%) and relative root mean square error (RRMSE) (%) of the estimated parameters evaluated from 500 simulated datasets

From: Clinical trial simulation to evaluate power to compare the antiviral effectiveness of two hepatitis C protease inhibitors using nonlinear mixed effect models: a viral kinetic approach

  All data (n = 7 VL) ML (n = 7 VL) ML (n = 5 VL)
  RB (%) RRMSE (%) RB (%) RRMSE (%) RB (%) RRMSE (%)
log10(V 0 ) (IU/mL) 0.1 1.0 0.2 1.0 0.1 1.0
c (day-1) 1.0 4.3 0.6 4.1 34.1 78.8
δ (day-1) 0.2 3.2 0.8 3.7 0.6 3.7
-log10(1-ϵ) 0.1 3.2 0.4 3.1 0.3 3.6
β 0.4 8.5 −0.5 8.5 0.4 9.9
ω 2 vo −0.4 18.9 −1.0 19.0 −0.5 19.3
ω 2 c −4.6 31.5 −10.9 32.9 236.6 358.3
ω 2 δ −3.0 19.8 −2.3 24.5 −2.4 24.9
ω 2 ϵ −2.6 32.2 −4.5 32.0 −9.9 36.3
σ −0.03 5.3 −0.7 6.2 −1.3 8.0
  1. Parameters were simulated with N = 30 patients per group assuming ϵ A = 0.999 and ϵ B = 0.990, no limit of detection (“All data”) or a limit of detection at 12 IU/mL (“ML”), and with n = 7 or 5 viral load (VL) measurements per patient.