|
ϵ
B
|
0.998
|
0.995
|
0.990
|
0.998
|
0.995
|
0.990
|
0.998
|
0.995
|
0.990
|
---|
Small sample size
|
Design*
|
N = 10 and n = 7
|
N = 14 and n = 5
|
N = 10 and n = 5
|
ntot = 70
|
ntot = 70
|
ntot =50
|
Wald test (uncorrected)
|
62.2
|
99.8
|
100
|
61.8
|
100
|
100
|
55.2
|
98.8
|
100
|
Wald test (corrected)
|
44.2
|
98.4
|
100
|
50.4
|
100
|
100
|
35.8
|
95.8
|
100
|
Wilcoxon test
|
6.6
|
11.2
|
26.8
|
4.4
|
15.6
|
39.0
|
6.6
|
11.2
|
26.8
|
|
Design*
|
N = 20 and n = 7
|
N = 28 and n = 5
|
N = 20 and n = 5
|
ntot = 140
|
ntot = 140
|
ntot = 100
|
Middle sample size
|
Wald test (uncorrected)
|
83.4
|
100
|
100
|
86.8
|
100
|
100
|
77.8
|
100
|
100
|
Wald test (corrected)
|
69.0
|
100
|
100
|
78.0
|
100
|
100
|
58.8
|
100
|
100
|
Wilcoxon test
|
7.0
|
23.0
|
50.4
|
6.8
|
30.4
|
64.6
|
7.0
|
23.0
|
50.4
|
Large sample size
|
Design*
|
N = 30 and n = 7
|
N = 42 and n = 5
|
N = 30 and n = 5
|
ntot = 210
|
ntot = 210
|
ntot = 150
|
Wald test (uncorrected)
|
94.0
|
100
|
100
|
86.8
|
100
|
100
|
89.4
|
100
|
100
|
Wald test (corrected)
|
89.2
|
100
|
100
|
82.6
|
100
|
100
|
82.6
|
100
|
100
|
Wilcoxon test
|
7.4
|
31.0
|
67.0
|
9.2
|
43.8
|
85.0
|
7.4
|
31.0
|
67.0
|
- * N: number of patients per group of treatment; n: number of viral load measurements per patient; ntot: total numbers of observations per group of treatment.