
ϵ
^{B}

0.998

0.995

0.990

0.998

0.995

0.990

0.998

0.995

0.990


Small sample size

Design*

N = 10 and n = 7

N = 14 and n = 5

N = 10 and n = 5

n_{tot} = 70

n_{tot} = 70

n_{tot} =50

Wald test (uncorrected)

62.2

99.8

100

61.8

100

100

55.2

98.8

100

Wald test (corrected)

44.2

98.4

100

50.4

100

100

35.8

95.8

100

Wilcoxon test

6.6

11.2

26.8

4.4

15.6

39.0

6.6

11.2

26.8


Design*

N = 20 and n = 7

N = 28 and n = 5

N = 20 and n = 5

n_{tot} = 140

n_{tot} = 140

n_{tot} = 100

Middle sample size

Wald test (uncorrected)

83.4

100

100

86.8

100

100

77.8

100

100

Wald test (corrected)

69.0

100

100

78.0

100

100

58.8

100

100

Wilcoxon test

7.0

23.0

50.4

6.8

30.4

64.6

7.0

23.0

50.4

Large sample size

Design*

N = 30 and n = 7

N = 42 and n = 5

N = 30 and n = 5

n_{tot} = 210

n_{tot} = 210

n_{tot} = 150

Wald test (uncorrected)

94.0

100

100

86.8

100

100

89.4

100

100

Wald test (corrected)

89.2

100

100

82.6

100

100

82.6

100

100

Wilcoxon test

7.4

31.0

67.0

9.2

43.8

85.0

7.4

31.0

67.0

 * N: number of patients per group of treatment; n: number of viral load measurements per patient; n_{tot}: total numbers of observations per group of treatment.