Table 4 Reviews on missing data and ITT in the BMJ, JAMA, NEJM and the Lancet 1
From: Handling missing data in RCTs; a review of the top medical journals
Study | Timing | Study inclusion criteria | Number of trials included | Number (%) of papers with missing data2 | Number (%) of papers with more than 10% missing data2 | Missing data approaches in primary analysis | Number (%)3 | Number (%) of papers reporting sensitivity analysis3 | Number (%) of papers reporting ITT4 |
|---|---|---|---|---|---|---|---|---|---|
Hollis et al., 1999 [2] | 1997 | All RCTs | 249 | 89/119 (75) | 29/119 (24) | Complete case | 44 (49) | 1 (1) | 119/249 (48) |
Simple imputation | 15 (17) | ||||||||
Multiple imputation | 0 | ||||||||
Model based | 29 (33) | ||||||||
Unclear | 1 (1) | ||||||||
Wood et al., 2004 [22] | July-Dec, 2001 | All RCTs with non-survival outcomes | 71 | 63/71 (89) | 36/71 (51) | Complete case | 41 (65) | 13 (21) | 26/63 (41) |
Simple imputation | 14 (22) | ||||||||
Multiple imputation | 1 (2) | ||||||||
Model based | 5 (8) | ||||||||
Unclear | 2 (3) | ||||||||
Gravel et al., 2007 [1] | 2002 | Sample of RCTs1 | 403 | 152/249 (61) | 52/249 (21) | Complete case | 89 (59) | Not reported | 249/403 (62) |
Simple imputation | 32 (21) | 201/283 (71)5 | |||||||
Multiple imputation | 1 (1) | ||||||||
Model based6 | 0 | ||||||||
Unclear6 | 30 (20) | ||||||||
Fielding et al., 2008 [21] | 2005-2006 | Random sample of RCTs with Quality of life outcomes | 61 | 55/61 (90) | 22/61 (36) | Complete case | 30 (55) | 6 (11) | Not reported |
Simple imputation | 11 (20) | ||||||||
Multiple imputation | 1 (2) | ||||||||
Model based | 9 (16) | ||||||||
Unclear | 4 (7) | ||||||||
Bell et al., (current study) | July-Dec, 2013 | All RCTS with non-survival outcomes | 77 | 73/77 (95) | 36/77 (47) | Complete case | 33 (45) | 27 (37) | 62/73 (85) |
Simple imputation | 20 (27) | ||||||||
Multiple imputation | 6 (8) | ||||||||
Model based | 14 (19) |