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Table 3 Patient clinical and HRQL measurements

From: Measuring health-related quality of life in chronic obstructive pulmonary disease: properties of the EQ-5D-5L and PROMIS-43 short form

Measure

No. of missing

Total sample [Mean (SD)]

GOLD 1 (n = 102) [Mean (SD)]

GOLD 2 (n = 353) [Mean (SD)]

GOLD 3 (n = 165) [Mean (SD)]

GOLD 4 (n = 50) [Mean (SD)]

ANOVA

RE ratio

ANOVA

Kruskal-Wallis test

       

F-stat

 

p-value

p-value

FACIT-Dyspnea

6

44.6 (8.4)

41.0 (7.9)

43.3 (8.0)

47.6 (8.0)

51.6 (6.9)

31.19

Ref

<.0001

<.0001

mMRC dyspnea

60

1.50 (0.99)

1.20 (0.95)

1.38 (0.95)

1.79 (0.95)

1.88 (1.06)

11.71

0.38

<.0001

<.0001

Borg dyspnea (at rest)

55

0.67 (1.08)

0.55 (0.91)

0.60 (1.07)

0.92 (1.19)

0.64 (0.97)

3.52

0.11

0.01

0.02

Borg dyspnea (during 6MWT)

60

2.52 (1.94)

2.07 (1.73)

2.27 (1.90)

3.02 (1.78)

3.78 (2.37)

13.06

0.42

<.0001

<.0001

6MWD

60

335.6 (110.4)

371.9 (111.2)

345.5 (109.4)

301.2 (103.1)

297.8 (101.3)

11.24

0.36

<.0001

<.0001

EQ-5D index

0

0.79 (0.15)

0.81 (0.14)

0.81 (0.14)

0.76 (0.17)

0.74 (0.15)

6.13

0.20

0.0004

0.002

EQ-VAS

0

70.6 (19.6)

76.6 (17.5)

72.6 (19.1)

65.7 (20.2)

61.1 (19.7)

12.24

0.39

<.0001

<.0001

PROMIS

          

 Physical function (P-PF)

0

40.6 (7.6)

43.2 (8.2)

41.7 (7.7)

38.3 (6.0)

35.3 (5.5)

21.41

0.69

<.0001

<.0001

 Anxiety (P-A)

0

49.7 (9.2)

49.5 (9.6)

49.3 (9.0)

50.0 (9.4)

52.3 (8.7)

1.69

0.05

0.17

0.15

 Depression (P-D)

0

48.3 (9.3)

49.3 (10.1)

47.3 (8.8)

48.5 (9.6)

51.8 (8.9)

4.08

0.13

0.007

0.01

 Fatigue (P-F)

0

50.8 (9.2)

51.2 (9.9)

50.0 (9.2)

51.3 (8.8)

53.9 (8.4)

3.01

0.10

0.03

0.04

 Sleep disturbance (P-SD)

0

49.8 (9.4)

51.5 (10.2)

49.3 (9.0)

50.0 (9.6)

48.9 (9.4)

1.64

0.05

0.18

0.23

 Social roles (P-SR)

2

48.1 (9.3)

49.3 (9.0)

49.0 (9.4)

46.3 (9.3)

44.7 (7.9)

6.07

0.19

0.0004

0.001

 Pain interference (P-PI)

3

53.9 (9.6)

53.8 (9.5)

54.3 (9.5)

53.3 (9.7)

53.1 (9.8)

0.56

0.02

0.64

0.74

 Pain intensity scale (P-P)

0

3.49 (2.67)

3.49 (2.69)

3.54 (2.62)

3.43 (2.70)

3.28 (2.90)

0.18

0.01

0.91

0.85

  1. 6MWD = six-minute walk distance; 6MWT = six-minute walk test; ANOVA = analysis of variance; GOLD = Global initiative for chronic Obstructive Lung Disease; FACIT = Factional Assessment of Chronic Illness Therapy; mMRC = modified Medical Research Council; PROMIS = Patient Reported Outcomes Measurement Information System; RE = relative efficiency; ref = reference group (RE = 1).
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BMC Medical Research Methodology

ISSN: 1471-2288

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