Axelsson et al. [10]
|
Sweden (Swedish)
|
AQEL
|
22
|
ACP. Median age = 67.5 years, mean and median KPS = 62.3 and 70, respectively.
|
71
|
30
|
3 days
|
Not described
|
Spearman Rank correlation
|
Cohen et al. [11]
|
Canada (English)
|
MQOL
|
16
|
ACP. Could be receiving chemotherapy. Mean age: 59 years). Life expectancy greater than 2 weeks.
|
100
|
49-59
|
2 days
|
Yes
|
ICC
|
Llobera et al. [12]
|
Spain (Spanish)
|
HRCA-QL index
|
5
|
APC (end-of-life). Median survival = 59 days.
|
200
|
39
|
1 month (mean)
|
Yes
|
ICC
|
Mystakidou et al. [13]
|
Greece (Hellenic)
|
PLQI
|
28
|
Patients with symptomatic incurable cancer. Off anticancer treatment for ≥ 3 months. All patients classified as ECOG-PS ≥ 2 (ECOG-PS3 = 68%).
|
120
|
120
|
7 days
|
No
|
Spearman Rank correlation
|
Steinhauser et al. [14]
|
USA (English)
|
QUAL-E
|
25
|
Terminal CHF, ESRD, COPD, and stage IV cancer (56%).
|
248
|
135-170
|
7 days
|
Yes
|
ICC
|
Lopes Ferreira et al. [15]
|
Portugal (Portuguese)
|
POS
|
10
|
ACP (life expectancy < 1 year), non-terminal, many of them undergoing chemotherapy.
|
109
|
30
|
7 days
|
No
|
Pearson correlation
|
Suárez-del-Real et al. [16]
|
Mexico (Spanish)
|
QLQ-C15-PAL
|
15
|
ACP undergoing exclusive palliative care. KPS < =70% = 78%.
|
83
|
30
|
15.7 days (mean)
|
No
|
Repeated measures ANOVA
|
Leppert et al. [17]
|
Poland (Polish)
|
QLQ-C15-PAL
|
15
|
ACP undergoing palliative care.
|
129
|
129
|
7 days
|
No
|
Spearman Rank correlation
|
Kim et al. [18]
|
Korea (Korean)
|
MQLS
|
32
|
Mortality rate during study = 80%, ECOG-PS > = 3 = 71.2%.
|
70
|
54-64
|
3 hours and 7 days
|
No
|
ICC
|
Kim et al. [19]
|
Korea (Korean)
|
HQLS
|
43
|
Advanced cancer patients under exclusive palliative care. ECOG-PS3/4 = 64.2%.
|
180
|
88
|
1-2 weeks
|
No
|
Not described
|
Serra-Prat et al. [20]
|
Spain (Spanish)
|
POS
|
10
|
ACP under palliative care. Mean KPS = 50.93%.
|
200
|
Not described
|
1 week
|
Yes
|
ICC
|
Eisenchlas et al. [21]
|
Argentina (Spanish)
|
POS
|
10
|
ACP under palliative care. ECOG-PS 3/4 = 58%.
|
65
|
24
|
2 days
|
No
|
Weighted kappa agreement
|
Guo et al. [22]
|
USA (English)
|
Brief Hospice Inventory
|
17
|
Geriatric population (mean age = 78 years, 83% ≥ 70 years) 47% Advanced cancer under hospice care in 47%.
|
145
|
63
|
1 week
|
No
|
Not described
|
Lo et al. [23]
|
China (Chinese)
|
MQOL
|
16
|
Incurable ACP.
|
462
|
20
|
2 days
|
No
|
ICC
|
Shahidi et al. [24]
|
Iran (Persian)
|
MQOL
|
16
|
Mean KPS = 74.8%. Any type of incurable cancer with an estimated life expectancy of < 12 months was considered for the study.
|
61
|
Not clearly stated
|
24-72 hours
|
No
|
Pearson correlation
|
Harding et al. [25]
|
South Africa and Uganda (most spoke IsiZulu1)
|
APCA African Palliative Outcome Scale
|
10
|
Hospice patients, including ACP. Limited self-care and completely disabled = 41.7%.
|
682
|
307
|
21.2 hours (mean)
|
No
|
ICC
|
Hearn et al. [26]
|
England and Scotland (English)
|
POS
|
10
|
ACP (98%) under palliative care. Limited activity or disabled = 47.1%.
|
168
|
34
|
3-7 days
|
Yes
|
Weighted kappa agreement
|
Wilson et al. [27]
|
Canada (English)
|
SISC
|
13
|
ACP under palliative care. Median survival = 46 days.
|
68
|
46
|
1-3 days
|
No
|
Pearson correlation
|
Agra et al. [28]
|
Spain (Spanish)
|
RSCL
|
39
|
ACP under palliative care. Terminal illness (life expectancy < 6 months). KPS < 70% in 65.2%.
|
118
|
116
|
24 hours
|
No
|
ICC
|
Chang et al. [29]
|
USA (English)
|
ESAS
|
10
|
ACP under palliative care. Mostly elderly male patients.
|
233
|
19-23
|
1 day and 1 week
|
No
|
Spearman Rank correlation
|
Stiel et al. [30]
|
Germany (German)
|
MIDOS
|
12
|
ACP under palliative care. ECOG-PS 3/4 = 56.6%.
|
60
|
60
|
1 day
|
No
|
Pearson correlation
|
Moro et al. [31]
|
Italy (Italian)
|
ESAS
|
10
|
ACP under exclusive palliative care. In-patients, KPS ≤ 40 = 75%. Median survival = 35 days.
|
241
|
60
|
24-48 hours
|
No
|
ICC
|
Mystakidou et al. [32]
|
Greece (Greek)
|
MDASI
|
19
|
ACP under palliative care. ECOG-PS 3/4 = 63%.
|
150
|
100
|
3 days
|
No
|
Pearson correlation
|
Pautex et al. [33]
|
Swiss (French)
|
ESAS
|
10
|
ACP under palliative care. Mean age = 72 years.
|
42
|
42
|
1 day
|
No
|
Paired t test
|
Stiel et al. [34]
|
Germany (German)
|
HOPE-SP-CL
|
16
|
ACP under palliative care; inpatients.
|
31,055
|
332-472
|
7 days
|
No
|
Spearman Rank correlation
|
Carvajal et al. [35]
|
Spain (Spanish)
|
ESAS
|
10
|
ACP under palliative care. KPS ≤ 70% = 45.5%.
|
171
|
146
|
0-6 hours
|
No
|
Spearman Rank correlation and Lin’s Concordance test
|
Radbruch et al. [36]
|
Germany (German)
|
MIDOS
|
12
|
ACP under palliative care. ECOG-PS 3/4 = 81.2%.
|
128
|
76
|
1-6 days
|
Yes
|
Pearson correlation
|
Kwon et al. [37]
|
Korea (Korean)
|
ESAS
|
10
|
Mostly symptomatic ACP undergoing active antineoplastic treatment.
|
162
|
162
|
2-4 hours
|
No
|
Pearson correlation
|
Aoun et al. [38]
|
Australia (English)
|
SAS
|
7
|
ACP under palliative care.
|
572
|
60
|
2 hours
|
Yes
|
ICC
|
Pereira et al. [39]
|
Portugal (Portuguese)
|
FACT-G
|
28
|
ACP under PC (end-of-life). Inpatients and outpatients. Performance status not described.
|
346
|
27
|
8-9 days
|
No
|
Pearson correlation
|
Sterkenburg et al. [40]
|
Canada (English)
|
MQLS
|
32
|
Most were ACP under palliative care. Mean survival = 49.56 days.
|
84
|
73
|
3 hours and 7 days
|
No
|
ICC
|