Table 3 Mediation analysis: Total, direct and indirect effects with 95% confidence intervals
From: Mediation analysis of the relationship between institutional research activity and patient survival
Effect (of trial hospital vs. non-trial hospital) | HR | 95% CI |
|---|---|---|
Total effect | 0.58 | [0.41; 0.80] |
Direct effect | 0.67 | [0.47; 0.92] |
Indirect effect (through surgery) | 0.93 | [0.84; 1.02] |
Indirect effect (through chemotherapy) | 0.93 | [0.84; 1.01] |
Indirect effect (through both surgery and chemotherapy) | 0.87 | [0.75; 0.98] |