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Table 2 Results of meta-analyses of trials of high intensity nursing to reduce smoking using standard§ and 'treat-as-one-trial' methods, with relative risk as effect measure

From: Meta-analysis, Simpson's paradox, and the number needed to treat

Setting (no. of trials)

Number quitting/total

Pooled risk ratio (95% CI)

NNT (95% CI)

 

Intervention

Control

  

Hospital (7)

435/1367

318/1295

  

   Meta-analysis

  

1.30 (1.16 to 1.47)

13.6 (8.7 to 25.5)¶¶

   Treat-as-one-trial

  

1.30 (1.15 to 1.47)

13.8 (9.4 to 25.9)

Primary Care (3) *

111/2453

41/1006

  

   Meta-analysis

  

1.01 (0.71 to 1.42)

2454 (58.4 to H84.6¶)¶¶

   Treat-as-one-trial

  

1.11 (0.78 to 1.58)

222.5 (52.0 to H97.7¶)

Primary Care (2) **

87/2246

25/958

  

   Meta-analysis

  

1.54 (0.97 to 2.44)

71.0 (26.6 to H1277¶)¶¶

   Treat-as-one-trial

  

1.48 (0.96 to 2.30)

79.1(39.2 to H4369¶)

  1. § Mantel-Haenszel method (fixed effect) * as defined by Moore et al ** excluding reference [12]¶ NNT for harm [13]¶¶NNT calculated using the event rate among controls and the relative risk reduction [4]