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Table 1 Sensitivity analyses for measured blood loss ≥ 1000 ml (severe post-partum haemorrhage, or SPPH)

From: The reporting of methods for reducing and detecting bias: an example from the WHO Misoprostol Third Stage of Labour equivalence randomised controlled trial

Assumed bias introduced

in SPPH by unblinding

due to shivering (mls)

Group

No. of women

No. of cases

%

RR

95% CI

500

Misoprostol

9214

295

3.2

1.23

(1.04 to 1.45)

 

Oxytocin

9228

241

2.6

  

400

Misoprostol

9214

307

3.3

1.27

(1.07 to 1.49)

 

Oxytocin

9228

243

2.6

  

300

Misoprostol

9214

313

3.4

1.29

(1.09 to 1.52)

 

Oxytocin

9228

243

2.6

  

200

Misoprostol

9214

322

3.5

1.28

(1.09 to 1.51)

 

Oxytocin

9228

251

2.7

  

100

Misoprostol

9214

334

3.6

1.31

(1.11 to 1.53)

 

Oxytocin

9228

256

2.8

  

0

Misoprostol

9214

366

4.0

1.39

(1.19 to 1.63)

 

Oxytocin

9228

263

2.9

  

-100

Misoprostol

9214

401

4.4

1.50

(1.29 to 1.75)

 

Oxytocin

9228

267

2.9

  

-200

Misoprostol

9214

453

4.9

1.64

(1.41 to 1.90)

 

Oxytocin

9228

277

3.0

  

-300

Misoprostol

9214

499

5.42

1.74

(1.51 to 2.00)

 

Oxytocin

9228

288

3.12

  

-400

Misoprostol

9214

591

6.41

1.94

(1.70 to 2.22)

 

Oxytocin

9228

305

3.31

  

-500

Misoprostol

9214

688

7.47

2.10

(1.85 to 2.39)

 

Oxytocin

9228

328

3.55