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Table 6 Realized α and 1 - β using simulations of the optimal designs for testing H0: S(1) ≤ .35. Power is specified for S(1) = .5.

From: Design of Phase II cancer trials evaluating survival probabilities

 

Desired α = .1, 1 - β = .9

Desired α = .05, 1 - β = .95

 

ETSL

EDA

ETSL

EDA

DA/x*

α

1 - β

α

1 - β

α

1 - β

α

1 - β

1.50

.103

.909

.100

.907

.049

.953

.043

.948

1.75

.104

.909

.114

.918

.049

.954

.045

.951

2

.126

.919

.089

.898

.050

.954

.051

.955

3

.092

.904

.116

.918

.045

.952

.059

.961

4

.092

.903

.091

.903

.045

.954

.048

.955