Simulation parameters1 | Type of imbalance | Bias | Mean Square Error | Empirical type I error2 | Empirical power2 | ||
---|---|---|---|---|---|---|---|
Intraclass correlation coefficient (ρ) | Number of clusters in each arm (g) | Total number of subjects in each arm (N) | |||||
0.005 | 5 | 485 | None | -0.0020 | 0.0062 | 0.0328 | 0.7756 |
Moderate | -0.0015 | 0.0062 | 0.0300 | 0.7800 | |||
Poisson | 0.0003 | 0.0061 | 0.0368 | 0.7814 | |||
Pareto | 0.0002 | 0.0100 | 0.0664 | 0.6432 | |||
0.005 | 10 | 326 | None | 0.0005 | 0.0070 | 0.0326 | 0.7868 |
Moderate | 0.0009 | 0.0073 | 0.0402 | 0.7838 | |||
Poisson | -0.0010 | 0.0070 | 0.0356 | 0.7884 | |||
Pareto | 0.0043 | 0.0100 | 0.0566 | 0.6968 | |||
0.005 | 20 | 282 | None | -0.0010 | 0.0072 | 0.0320 | 0.7942 |
Moderate | 0.0014 | 0.0075 | 0.0398 | 0.7878 | |||
Poisson | -0.0010 | 0.0076 | 0.0408 | 0.7802 | |||
Pareto | 0.0000 | 0.0090 | 0.0486 | 0.7258 | |||
0.005 | 40 | 265 | None | 0.0006 | 0.0078 | 0.0444 | 0.7848 |
Moderate | 0.0011 | 0.0082 | 0.0458 | 0.7936 | |||
Poisson | -0.0017 | 0.0082 | 0.0484 | 0.7772 | |||
Pareto | 0.0000 | 0.0086 | 0.0466 | 0.7572 | |||
0.020 | 10 | 629 | None | -0.0017 | 0.0070 | 0.0448 | 0.8012 |
Moderate | 0.0017 | 0.0073 | 0.0544 | 0.7974 | |||
Poisson | 0.0009 | 0.0074 | 0.0510 | 0.7992 | |||
Pareto | -0.0022 | 0.0118 | 0.0904 | 0.6236 | |||
0.020 | 20 | 353 | None | -0.0004 | 0.0073 | 0.0452 | 0.8000 |
Moderate | 0.0006 | 0.0074 | 0.0408 | 0.7980 | |||
Poisson | -0.0007 | 0.0075 | 0.0458 | 0.7968 | |||
Pareto | 0.0009 | 0.0115 | 0.0660 | 0.6546 | |||
0.020 | 40 | 290 | None | 0.0017 | 0.0080 | 0.0518 | 0.7932 |
Moderate | 0.0001 | 0.0077 | 0.0466 | 0.7944 | |||
Poisson | -0.0003 | 0.0077 | 0.0466 | 0.7912 | |||
Pareto | 0.0003 | 0.0101 | 0.0556 | 0.7008 | |||
0.050 | 20 | 743 | None | -0.0007 | 0.0075 | 0.0436 | 0.7916 |
Moderate | -0.0018 | 0.0077 | 0.0540 | 0.8026 | |||
Poisson | -0.0003 | 0.0078 | 0.0536 | 0.7950 | |||
Pareto | -0.0022 | 0.0115 | 0.0562 | 0.6256 | |||
0.050 | 40 | 361 | None | -0.0012 | 0.0080 | 0.0528 | 0.7944 |
Moderate | 0.0031 | 0.0080 | 0.0510 | 0.7926 | |||
Poisson | -0.0001 | 0.0080 | 0.0502 | 0.7904 | |||
Pareto | -0.0023 | 0.0121 | 0.0604 | 0.6242 | |||
0.100 | 40 | 652 | None | 0.0021 | 0.0076 | 0.0504 | 0.7966 |
Moderate | 0.0013 | 0.0078 | 0.0458 | 0.8118 | |||
Poisson | -0.0022 | 0.0078 | 0.0506 | 0.7946 | |||
Pareto | -0.0031 | 0.0121 | 0.0546 | 0.6006 |