Figure 1From: Pragmatic trials in primary care. Methodological challenges and solutions demonstrated by the DIAMOND-studyDIAMOND: Treatment strategies. * If the symptoms persisted the patient continued with the next treatment step. If the symptoms initially were relieved but relapsed within 4 weeks after stopping the treatment step, the patient also started the next treatment step. Otherwise (in case of a relapse after 4 weeks), the GP could treat the patient to their own judgement. Antacids (Algedrate-Magesiumoxide); H2RA: H2-receptor antagonist (Raniditine); PPI: Proton Pump Inhibitor (Pantozole).Back to article page