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Table 2 Oral anticoagulation study characteristics

From: Assessing differential attrition in clinical trials: self-monitoring of oral anticoagulation and type II diabetes

Source Inclusion Criteria Duration of study mths. Nos. assigned to Intervention & (%) drop out Nos assigned to Control & (%) drop out Intervention for self-monitoring group Control group intervention
38 White 1989, US Inpatients with a duration of OAT of at least 8 weeks § 2 26 (11.5) 24 (4.2) Management by general internists ACC
29 Horstkotte 1998, Germany Outpatients with the St Jude Medical prosthesis ‡ N/A 75 (1.3) 75 (0) INR twice a week and contact clinic by phone PCP
34 Sawicki 1999, Germany Any indication for anticoagulation and life long treatment ‡ 6 90 (14.4) 90 (7.8) 3 educational sessions. SM PCP
23 Beyth 2000, US Inpatients § 6 163 (22.1) 162 (0) 1-hour education session and contact clinic by phone PCP
24 Cromheecke 2000, Holland Long term OAT at least 6 months treatment ‡ 3 101 (0) 100 (0) 2-educational sessions, SM ACC
32 Kortke 2001, Germany Patients after mechanical heart valve surgery ‡ 24 305 (8.9) 295 (21.4) Trained in self-monitoring 6–11 days after operation PCP
35 Sidhu 2001, UK Patients after mechanical heart valve surgery ‡ 24 51 (33.3) 49 (2.0) 2-educational sessions, SM PCP
25 Fitzmaurice 2000, UK Long term OAT at least 6 months treatment ‡ 6 30 (23.3) 26 (0) 2-educational workshops, SM PCP
27 Gadisseur 2003, Holland Long term OAT at least 3 months treatment ‡ 6 99 (19.2) 161 (0) 3 educational sessions. SM by telephone ACC
28 Gardiner 2004, UK Long term OAT At least 8 months ‡ 6 44 (43.2) 40 (2.5) 2-educational sessions 1 week apart ACC
31 Khan 2004, UK At least 12 months OAT with AF. Age > 65 yrs ‡ 6 44 (9.1) 41 (4.9) 2 hour education session, contact by phone ACC
36 Sunderji 2004, Canada OAT for at least 1 month ¤ 8 70 (28.6) 70 (0) 2-educational sessions, SM PCP
33 Menendez-Jandula 2005, Spain OAT for at least 3 months therapy ‡ 11.8 368 (21.5) 369 (2.4) 2-educational sessions, taught by nurse. SM ACC
37 Voller 2005, Germany long term OAT with non valvular AF ‡ 5 101 (19.8) 101 (0) Standard training course of 3 sessions PCP
26 Fitzmaurice 2005, UK Unselected patients in a general practice population 12 337 (41.5) 280 (13.2) 2-educational sessions, taught by nurse. SM PCP or ACC
30 Katz Unpublished, US Long term OAT attending anticoagulation clinic ‡ 12 101(0) 100(0) All patients were trained by nurse, video, and tested with a skills and knowledge checklist prior to randomization ACC
  1. § Coumatrack Monitor ‡ Coagucheck System ¤ Pro time Microcoagulation system ACC: Anticoagulation Clinic Care PCP: Primary Care physician managed SM: self adjusted treatment
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BMC Medical Research Methodology

ISSN: 1471-2288

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