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Table 2 Baseline scores and outcome comparisons, stratified by SF-36 scales.

From: Assessing the order of magnitude of outcomes in single-arm cohorts through systematic comparison with corresponding cohorts: An example from the AMOS study

SF-36 scale Baseline Follow-up
  AMOS patients (N = 392 patients in 5 cohorts) Corresponding cohorts (N = 552 cohorts) Outcome differences (N = 552 comparisons)
  Mean * SD * Median * N Mean ** SD ** Median ** Mean *** SD *** 25-per *** Median *** 75-per ***
Physical Function 72.8 23.8 80.0 62 65.1 19.2 68.6 0.6 9.4 -2.0 2.0 4.4
Role Physical 37.4 38.5 25.0 59 40.0 18.3 43.4 4.1 14.1 -6.3 5.0 12.4
Role Emotional 42.4 41.5 33.3 59 59.2 16.6 62.2 -0.2 11.3 -7.5 -2.0 7.7
Social Functioning 54.8 25.1 50.0 66 61.0 12.9 60.7 2.6 9.2 -2.8 2.0 8.8
Mental Health 49.3 20.9 48.0 62 61.9 10.9 64.0 2.0 6.7 -0.9 2.2 6.4
Bodily Pain 48.8 28.1 41.0 64 45.8 15.5 44.8 2.7 10.0 -1.7 2.8 9.2
Vitality 34.3 18.0 35.0 60 45.6 9.6 47.4 3.4 6.9 -1.0 3.9 8.7
General Health 48.3 19.9 47.0 63 60.3 10.2 60.3 2.9 5.4 -1.3 4.0 6.9
Physical Component 41.7 10.2 41.3 27 37.3 7.6 37.7 1.5 3.9 -0.3 2.4 3.9
Mental Component 35.6 12.7 34.0 30 40.4 7.7 42.4 0.3 5.0 -3.6 -0.5 3.7
  1. *of patients. **of cohorts. ***of differences. N: Number of cohorts. 25-per: 25-percentile. 75-per: 75-percentile. Each outcome difference refers to one SF-36 scale at the last evaluable follow-up of the corresponding cohort: Mean difference from baseline in AMOS cohort minus mean difference from baseline in corresponding cohort. A positive difference indicates that AMOS cohorts show larger improvements than corresponding cohorts.