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Table 4 Outcome comparisons in effect sizes, stratified by SF-36 scales. Each comparison refers to one SF-36 scale at the last evaluable follow-up of the corresponding cohort: Mean difference from baseline in AMOS cohort minus mean difference from baseline in corresponding cohort, divided by standard deviation of baseline score of AMOS cohort. A positive difference indicates that AMOS cohorts show larger improvements than corresponding cohorts.

From: Assessing the order of magnitude of outcomes in single-arm cohorts through systematic comparison with corresponding cohorts: An example from the AMOS study

SF-36 scale Median Interquartile range Ranges: Number (percentage) of comparisons N (total)
    ≤ -0.8 -0.79 to -0.5 -0.49 to -0.2 -0.19 to 0.19 0.2 to 0.49 0.5 to 0.79 ≥ 0.8  
Physical Functioning 0.09 -0.09 to 0.20 4 (6) 2 (3) 6 (10) 35 (56) 12 (19) 1 (2) 2 (3) 62 (100)
Role Physical 0.13 -0.16 to 0.35 0 (0) 1 (2) 10 (17) 24 (41) 17 (29) 6 (10) 1 (2) 59 (100)
Role Emotional -0.05 -0.18 to 0.21 1 (2) 1 (2) 10 (17) 32 (54) 13 (22) 2 (3) 0 (0) 59 (100)
Social Functioning 0.09 -0.12 to 0.37 0 (0) 6 (9) 7 (11) 24 (36) 18 (27) 6 (9) 5 (8) 66 (100)
Mental Health 0.12 -0.05 to 0.33 2 (3) 2 (3) 4 (6) 28 (45) 18 (29) 6 (10) 2 (3) 62 (100)
Bodily Pain 0.12 -0.06 to 0.44 4 (6) 3 (5) 5 (8) 25 (39) 13 (20) 11 (17) 3 (5) 64 (100)
Vitality 0.23 -0.06 to 0.52 1 (2) 3 (5) 7 (12) 16 (27) 18 (30) 11 (18) 4 (7) 60 (100)
General Health 0.20 -0.06 to 0.36 0 (0) 1 (2) 6 (10) 24 (38) 24 (38) 8 (13) 0 (0) 63 (100)
Physical Component Summary 0.27 -0.03 to 0.36 1 (4) 1 (4) 4 (15) 7 (26) 10 (37) 4 (15) 0 (0) 27 (100)
Mental Component Summary -0.03 -0.31 to 0.34 2 (7) 2 (7) 6 (20) 10 (33) 6 (20) 3 (10) 1 (3) 30 (100)