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Table 4 Outcome comparisons in effect sizes, stratified by SF-36 scales. Each comparison refers to one SF-36 scale at the last evaluable follow-up of the corresponding cohort: Mean difference from baseline in AMOS cohort minus mean difference from baseline in corresponding cohort, divided by standard deviation of baseline score of AMOS cohort. A positive difference indicates that AMOS cohorts show larger improvements than corresponding cohorts.

From: Assessing the order of magnitude of outcomes in single-arm cohorts through systematic comparison with corresponding cohorts: An example from the AMOS study

SF-36 scale

Median

Interquartile range

Ranges: Number (percentage) of comparisons

N (total)

   

≤ -0.8

-0.79 to -0.5

-0.49 to -0.2

-0.19 to 0.19

0.2 to 0.49

0.5 to 0.79

≥ 0.8

 

Physical Functioning

0.09

-0.09 to 0.20

4 (6)

2 (3)

6 (10)

35 (56)

12 (19)

1 (2)

2 (3)

62 (100)

Role Physical

0.13

-0.16 to 0.35

0 (0)

1 (2)

10 (17)

24 (41)

17 (29)

6 (10)

1 (2)

59 (100)

Role Emotional

-0.05

-0.18 to 0.21

1 (2)

1 (2)

10 (17)

32 (54)

13 (22)

2 (3)

0 (0)

59 (100)

Social Functioning

0.09

-0.12 to 0.37

0 (0)

6 (9)

7 (11)

24 (36)

18 (27)

6 (9)

5 (8)

66 (100)

Mental Health

0.12

-0.05 to 0.33

2 (3)

2 (3)

4 (6)

28 (45)

18 (29)

6 (10)

2 (3)

62 (100)

Bodily Pain

0.12

-0.06 to 0.44

4 (6)

3 (5)

5 (8)

25 (39)

13 (20)

11 (17)

3 (5)

64 (100)

Vitality

0.23

-0.06 to 0.52

1 (2)

3 (5)

7 (12)

16 (27)

18 (30)

11 (18)

4 (7)

60 (100)

General Health

0.20

-0.06 to 0.36

0 (0)

1 (2)

6 (10)

24 (38)

24 (38)

8 (13)

0 (0)

63 (100)

Physical Component Summary

0.27

-0.03 to 0.36

1 (4)

1 (4)

4 (15)

7 (26)

10 (37)

4 (15)

0 (0)

27 (100)

Mental Component Summary

-0.03

-0.31 to 0.34

2 (7)

2 (7)

6 (20)

10 (33)

6 (20)

3 (10)

1 (3)

30 (100)