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Table 7 Outcome comparisons in effect sizes: Sensitivity analyses (SA)

From: Assessing the order of magnitude of outcomes in single-arm cohorts through systematic comparison with corresponding cohorts: An example from the AMOS study

Analysis Median Interquartile range Ranges: Number (percentage) of comparisons N (total) N
    ≤ -0.8 -0.79 to -0.5 -0.49 to -0.2 -0.19 to 0.19 0.2 to 0.49 0.5 to 0.79 ≥ 0.8 Comparisons Cohorts
Main analysis: any design, setting, intervention, and baseline status 0.11 -0.11 to 0.35 13 (3) 20 (4) 58 (11) 214 (41) 142 (27) 53 (10) 17 (3) 517 (100) 84
SA1: Design: only observational studies (excluding randomised controlled trials) 0.08 -0.14 to 0.28 6 (2) 11 (4) 40 (13) 140 (47) 77 (26) 21 (7) 6 (2) 301 (100) 44
SA2: Setting: only primary care/health maintenance organization 0.24 0.03 to 0.38 3 (2) 4 (3) 9 (7) 42 (30) 60 (43) 16 (12) 4 (3) 138 (100) 27
SA3: Intervention: only drugs, physiotherapy, other physical therapy, or mixed 0.08 -0.09 to 0.30 3 (1) 7 (2) 36 (11) 164 (50) 86 (26) 21 (6) 8 (2) 325 (100) 49
SA4: Baseline status: only comparisons with small baseline difference (< 0.50 standard deviation) 0.08 -0.13 to 0.28 5 (1) 14 (4) 41 (12) 161(47) 81 (24) 29 (9) 9 (3) 340 (100) 81
SA1 + SA2 + SA3 + SA4 0.07 -0.03 to 0.19 0 (0) 0 (0) 2 (13) 10 (63) 3 (19) 0 (0) 1 (6) 16 (100) 5