Measurement of skeletal related events in SEER-Medicare: a comparison of claims-based methods

Aly, Abdalla; Onukwugha, Eberechukwu; Woods, Corinne; Mullins, C. Daniel; Kwok, Young; Qian, Yi; Arellano, Jorge; Balakumaran, Arun; Hussain, Arif

doi:10.1186/s12874-015-0047-5

BMC Medical Research Methodology

Table 1 Clinical and demographic characteristics of men with mPC according to code definition

From: Measurement of skeletal related events in SEER-Medicare: a comparison of claims-based methods

			Base case definition					Alternative definition
	Overall		Yes		No			Yes		No
	(N = 8997)		(N = 4176)		(N = 4821)			(N = 3851)		(N = 5146)
	N	(%)^a	N	(%)^b	N	(%)^b	P value	N	(%)^b	N	(%)^b	P value
Age	1528	17.0	803	52.6	725	47.4	<0.01	794	52.0	734	48.0	<0.01
ᅟ66–70	1528	17.0	803	52.6	725	47.4		794	52.0	734	48.0
ᅟ71–75	1801	20.0	908	50.4	893	49.6		895	49.7	906	50.3
ᅟ76–80	1995	22.2	942	47.2	1053	52.8		874	43.8	1121	56.2
ᅟ80<	3673	40.8	1523	41.5	2150	58.5		1288	35.1	2385	64.9
Race/Ethnicity	6762	75.2	3274	48.4	3488	51.6	<0.01	3001	44.4	3761	55.6	<0.01
ᅟNon-Hispanic White	6762	75.2	3274	48.4	3488	51.6		3001	44.4	3761	55.6
ᅟNon-Hispanic Black	1282	14.3	445	34.7	837	65.3		411	32.0	871	68.0
ᅟHispanic	546	6.1	254	46.5	292	53.5		243	44.5	303	55.5
ᅟOther	407	4.4	203	49.9	204	50.1		196	48.2	211	51.8
Married	5216	58.0	2515	48.2	2701	51.8	<0.01	2385	45.7	2831	54.3	<0.01
Charlson Comorbidity Index	4871	54.1	2416	49.60	2455	50.40	<0.01	2280	46.81	2591	53.19	<0.01
ᅟ0	4871	54.1	2416	49.60	2455	50.40		2280	46.81	2591	53.19
ᅟ1	1713	19.0	828	48.34	885	51.66		742	43.32	971	56.68
ᅟ2	777	8.6	333	42.86	444	57.14		289	37.19	488	62.81
ᅟ3+	722	8.1	286	39.61	436	60.39		259	35.87	463	64.13
ᅟMissing	914	10.2	313	34.25	601	65.75		281	30.74	633	69.26
Poor Performance Status	1003	11.2	416	43.21	587	56.79	<0.01	350	37.34	653	62.66	<0.01
Gleason score							<0.01					<0.01
ᅟ2–6	206	2.3	78	37.86	128	62.14		77	37.38	129	62.62
ᅟ7	663	7.4	287	43.29	376	56.71		285	42.99	378	57.01
ᅟ8	771	8.6	355	46.04	416	53.96		335	43.45	436	56.55
ᅟ9	1224	13.6	577	47.14	647	52.86		557	45.51	667	54.49
ᅟ10	290	3.2	154	53.10	136	46.90		145	50.00	145	50.00
ᅟNot done/Unknown	5843	64.9	2725	46.64	3118	53.36		2452	41.96	3391	58.04
Poorly differentiated tumor	3423	38.1	1563	45.66	1860	54.34	0.06	1390	40.61	2033	59.39	<0.01
High PSA at baseline	7298	81.1	3415	46.79	3883	53.21	0.14	3185	43.64	4113	56.36	<0.01

Base case definition included codes identified under the ‘high specificity’ lists of RAD and SCC and codes under the ‘high sensitivity’ list of PF (in addition to all BS codes); Alternative definition included codes identified under the ‘high specificity’ list of PF and codes under the ‘high sensitivity’ lists of RAD and SCC (in addition to all BS codes). The Pearson χ² was used to statistically test for significance of differences in the frequency distributions of categorical variables. A p value of <0.05 was considered statistically significant
^acolumn percent
^brow percent

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ISSN: 1471-2288

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