Skip to main content

Advertisement

Fig. 2 | BMC Medical Research Methodology

Fig. 2

From: A general framework for comparative Bayesian meta-analysis of diagnostic studies

Fig. 2

Summary of simulation results. Bias in estimates of the contrasts in diagnostic accuracy from the proposed meta-analytical models applied in the simulation study. The boxplots present the bias in \(\hat {S}_{D12}\) and \(\hat {C}_{D12}\) (first row), \(\hat {S}_{RR12}\) and \(\hat {C}_{RR12}\) (second row), \(\hat {S}_{OR12}\) and \(\hat {C}_{OR12}\) (third row). The first column presents Scenario 1 where a common imperfect reference standard with moderate S and high C was used, the second scenario 2 where systematic bias is induced by differing reference standards. Full explanation of the model is in the text; full explanation of the simulation setup and results in Additional file 3. Note for Scenario 1: For models 1 to 3 disease status was estimated from the results of T4. Note for Scenario 2: Models 4 and 5 were applied both assuming it is known that the reference tests differ across studies (4a and 5a) and ignoring the difference in reference tests (4b and 5b)

Back to article page