Skip to main content

Advertisement

Table 1 Relative efficiency of single- and mixed-strain designs for each type of effect. The numbers of cages are the median required amounts to achieve 80 % power in the mixed- and single-strain designs. Test statistics are based on a Mann Whitney test (n = 52). See Additional file 1: Tables S2–S4 for details

From: Mixed-strain housing for female C57BL/6, DBA/2, and BALB/c mice: validating a split-plot design that promotes refinement and reduction

Effect Median number of cages in the single-strain design (inter-quartile range) Median number of cages needed for equivalent power in the mixed-strain design (inter-quartile range) Test Statistics
Enrichment 252 (96 - >600) 66 (30–456) Z = 1.74; p = 0.081
Strain 30 (12–108) 12 (12–42) Z = 2.18; p = 0.029
Strain*Enrichment 282 (96 - >600) 120 (54–258) Z = 1.96; p = 0.049