Skip to main content

Advertisement

Table 1 Results from different methods of adjusting for continuous covariates in APC and MIST2 trials

From: A comparison of methods to adjust for continuous covariates in the analysis of randomised trials

  APC   MIST2  
Analysis methods HR (95 % CI) P-value OR (95 % CI) P-value
Unadjusted 0.84 (0.68 to 1.04) 0.11 0.23 (0.05 to 1.15) 0.07
Dichotomised 0.82 (0.66 to 1.01) 0.06 0.21 (0.04 to 1.07) 0.06
Categorised 0.82 (0.66 to 1.01) 0.07 0.18 (0.03 to 0.94) 0.04
Linear 0.79 (0.64 to 0.98) 0.03 0.16 (0.03 to 0.87) 0.03
FP1 0.79 (0.64 to 0.98) 0.03 0.17 (0.03 to 0.90) 0.04
FP2 0.78 (0.63 to 0.97) 0.03 0.17 (0.03 to 0.90) 0.04
Splines (3 knots) 0.80 (0.64 to 0.99) 0.04 0.18 (0.03 to 0.96) 0.04
Splines (5 knots) 0.81 (0.65 to 1.00) 0.06 0.17 (0.03 to 0.91) 0.04