Table 1 Results from different methods of adjusting for continuous covariates in APC and MIST2 trials
From: A comparison of methods to adjust for continuous covariates in the analysis of randomised trials
| Â | APC | Â | MIST2 | Â |
|---|---|---|---|---|
Analysis methods | HR (95Â % CI) | P-value | OR (95Â % CI) | P-value |
Unadjusted | 0.84 (0.68 to 1.04) | 0.11 | 0.23 (0.05 to 1.15) | 0.07 |
Dichotomised | 0.82 (0.66 to 1.01) | 0.06 | 0.21 (0.04 to 1.07) | 0.06 |
Categorised | 0.82 (0.66 to 1.01) | 0.07 | 0.18 (0.03 to 0.94) | 0.04 |
Linear | 0.79 (0.64 to 0.98) | 0.03 | 0.16 (0.03 to 0.87) | 0.03 |
FP1 | 0.79 (0.64 to 0.98) | 0.03 | 0.17 (0.03 to 0.90) | 0.04 |
FP2 | 0.78 (0.63 to 0.97) | 0.03 | 0.17 (0.03 to 0.90) | 0.04 |
Splines (3 knots) | 0.80 (0.64 to 0.99) | 0.04 | 0.18 (0.03 to 0.96) | 0.04 |
Splines (5 knots) | 0.81 (0.65 to 1.00) | 0.06 | 0.17 (0.03 to 0.91) | 0.04 |