From: A scoping review of indirect comparison methods and applications using individual patient data
Characteristic | IPD-NMA studiesa | MAIC studiesa | Totala |
---|---|---|---|
Design of studies included in analyses | |||
RCTs | 21 (70) | 9 (30) | 30 (91) |
RCTs + observational | 1 (100) | 0 (0) | 1 (3) |
RCTs + quasi-RCTs | 1 (100) | 0 (0) | 1 (3) |
RCTs, non-RCTs, CBA | 1 (100) | 0 (0) | 1 (3) |
Total | 24 (73) | 9 (27) | 33 (100) |
Fixed- or random-effects model | |||
Random-effects model | 10 (100) | 0 (0) | 10 (30) |
Fixed-effect model | 7 (100) | 0 (0) | 7 (21) |
Fixed- and random-effects models | 5 (100) | 0 (0) | 5 (15) |
Not reported/not applicable | 2 (18) | 9 (82) | 11 (33) |
Total | 24 (73) | 9 (27) | 33 (100) |
Between-study variance estimator/prior | |||
Non-informative prior | 10 (100) | 0 (0) | 10 (67) |
Informative prior | 1 (100) | 0 (0) | 1 (7) |
Minimally informative prior | 1 (100) | 0 (0) | 1 (7) |
DL [72] | 1 (100) | 0 (0) | 1 (7) |
REML [73] | 1 (100) | 0 (0) | 1 (7) |
Not reported | 1 (100) | 0 (0) | 1 (7) |
Total | 15 (100) | 0 (0) | 15 (100) |
Methods used to compare different models | |||
DIC [74] | 10 (100) | 0 (0) | 10 (30) |
Statistical significance of regression coefficients and between-study variance | 3 (100) | 0 (0) | 3 (9) |
DIC and residual deviance [74] | 2 (100) | 0 (0) | 2 (6) |
Comparison of point estimates and their CIs | 0 (0) | 2 (100) | 2 (6) |
0 (0) | 1 (100) | 1 (3) | |
1 (100) | 0 (0) | 1 (3) | |
Not applicable | 8 (57) | 6 (43) | 14 (42) |
Total | 24 (73) | 9 (27) | 33 (100) |
Statistical techniques used for missing participant data | |||
LOCF | 2 (67) | 1 (33) | 3 (9) |
MCMC multiple imputations | 2 (100) | 0 (0) | 2 (6) |
ACA | 1 (100) | 0 (0) | 1 (3) |
LOCF and ACA | 0 (0) | 1 (100) | 1 (3) |
Not reported/unclear | 19 (73) | 7 (27) | 26 (79) |
Total | 24 (73) | 9 (27) | 33 (100) |
Methods used to rank treatment effectiveness/safety | |||
Probability of being the best | 11 (100) | 0 (0) | 11 (33) |
Not reported/not applicable | 13 (59) | 9 (41) | 22 (67) |
Total | 24 (73) | 9 (27) | 33 (100) |
Assessment of consistency assumption | |||
Yes | 13 (100) | 0 (0) | 13 (39) |
No/unclear | 6 (75) | 2 (25) | 8 (24) |
Not applicable | 5 (42) | 7 (58) | 12 (36) |
Total | 24 (73) | 9 (27) | 33 (100) |
Methods used to assess consistency assumption | |||
Informal approachesb | 8 (100) | 0 (0) | 8 (62) |
1 (100) | 0 (0) | 1 (8) | |
1 (100) | 0 (0) | 1 (8) | |
Lu and Ades [79] | 1 (100) | 0 (0) | 1 (8) |
Lumley [70] | 1 (100) | 0 (0) | 1 (8) |
Node-splitting [78] | 1 (100) | 0 (0) | 1 (8) |
Total | 13 (100) | 0 (0) | 13 (100) |
Inclusion of different treatment doses | |||
No | 18 (75) | 6 (25) | 24 (73) |
Yes | 6 (67) | 3 (33) | 9 (27) |
Total | 24 (73) | 9 (27) | 33 (100) |
Approaches used to account for different treatment doses | |||
Lumping doses | 4 (80) | 1 (20) | 5 (56) |
Splitting doses | 2 (50) | 2 (50) | 4 (44) |
Total | 6 (67) | 3 (33) | 9 (100) |
Software | |||
WinBUGS [55] | 7 (100) | 0 (0) | 7 (21) |
SAS [80] | 2 (33) | 4 (67) | 6 (18) |
5 (100) | 0 (0) | 5 (15) | |
OpenBUGS [54] | 2 (100) | 0 (0) | 2 (6) |
2 (100) | 0 (0) | 2 (6) | |
1 (100) | 0 (0) | 1 (3) | |
Stata [82] | 1 (100) | 0 (0) | 1 (3) |
Not reported | 4 (44) | 5 (56) | 9 (27) |
Total | 24 (73) | 9 (27) | 33 (100) |