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Table 1 Response options proposed to participants in the two clinical vignettes depending on baseline risk used

From: How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers

 

Proportion of pain control in the experimental group when baseline risk was:

Vignette 1

Low (90 %)

High (50 %)

Trial of a new analgesic to control pain in mild trauma injuries.

90.5

91.0

92.0

95.0

97.0

100.0

Open field

51.0

55.0

60.0

70.0

80.0

90.0

Open field

 

Proportion of mortality/cancer recurrence in the experimental group when baseline risk was:

Vignette 2

Low (10 %)

High (60 %)

Trial of a new adjuvant chemotherapy following primary surgery for an unnamed cancer in adults.

9.9

9.5

9.0

8.0

5.0

0.0

Open field

59.9

59.5

58.0

55.0

50.0

40.0

30.0

Open field