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Table 3 Experimental factors associated with the difference to be detected to control pain in mild trauma injuries presented as an absolute risk difference and as odds ratios

From: How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers

  Difference to be detected Difference to be detected expressed as odds ratio
Factors tested Mean gain in pain controla, % (95 % CI) P-value Mean odds ratio (95 % CI) P-value
Baseline risk   <0.001   0.017
 Low risk (90 % of controlled pain) (n = 186)
 High risk (50 % of controlled pain) (n = 184)
6.0 (4.9–7.1)
16.0 (14.9–17.1)
2.3 (2.1–2.5)
2.0 (1.9–2.2)
Study population   0.065   0.082
 Adults (n = 188)
 Children (n = 182)
10.3 (9.2–11.3)
11.7 (10.6–12.8)
2.1 (1.9–2.2)
2.3 (2.1–2.4)
Difficulties to recruit patients in the trial   0.111   0.029
 No difficulty to recruit patients (n = 183)
 Difficulties to recruit patients (n = 187)
10.3 (9.3–11.4)
11.6 (10.5–12.7)
2.0 (1.9–2.2)
2.3 (2.1–2.5)
Disadvantages of the new treatment   0.135   0.123
 Risk of minor digestive side effects (n = 183)
 Risk of severe allergic reactions (n = 187)
10.4 (9.3–11.5)
11.6 (10.5–12.6)
2.1 (1.9–2.2)
2.2 (2.1–2.4)
  1. 95 % CI 95 % confidence interval
  2. aMarginal means from the multivariable linear regression model