| Number of Subjects | PREOP | PACU | POD2 |
---|---|---|---|---|
(a) Matched Analysis of Delirium as the Outcome vs IL-6 as the Outcome | ||||
Matched Analysisa | ||||
 Delirium as the Outcome | 78 (39:39) |  |  |  |
 Beta (SE) |  | 0.00745 (0.0112) | 0.00321 (0.00327) | 0.0154 (0.0054) |
  P-value |  | 0.508 | 0.326 | 0.005 |
 Odds Ratio (95% CI) |  | 1.01 (0.99–1.03) | 1.00 (0.99–1.01) | 1.02 (1.01–1.03) |
Matched Analysisb | ||||
 IL-6 as the Outcome | 78 (39:39) |  |  |  |
 MPD |  | 1.11 | 9.13 | 50.44 |
  P-value |  | 0.475 | 0.123 | 0.005 |
(b) Matched Analysis Using Observed IL-6 vs. Unmatched Analysis Using Simulated IL-6 | ||||
Unmatched Analysis | ||||
 Simulated IL-6c | 192 (49:143) |  |  |  |
 Beta (SE) |  | -0.0385 (0.0322) | 0.00323 (0.002) | 0.0176 (0.004) |
  P-value |  | 0.231 | 0.105 | 0.0001 |
 Odds Ratio (95% CI) |  | 0.96 (0.90–1.03) | 1.00 (0.99–1.01) | 1.02 (1.01–1.03) |
Matched Analysis | ||||
 Observed IL-6d | 78 (39:39) |  |  |  |
 Beta (SE) |  | 0.00745 (0.0112) | 0.00321 (0.00327) | 0.0154 (0.0054) |
  P-value |  | 0.508 | 0.326 | 0.005 |
 Odds Ratio (95% CI) |  | 1.01 (0.99–1.03) | 1.00 (0.99–1.01) | 1.02 (1.01–1.03) |