
Number of Subjects

PREOP

PACU

POD2


(a) Matched Analysis of Delirium as the Outcome vs IL6 as the Outcome

Matched Analysis^{a}

Delirium as the Outcome

78 (39:39)
   
Beta (SE)
 
0.00745 (0.0112)

0.00321 (0.00327)

0.0154 (0.0054)

Pvalue
 
0.508

0.326

0.005

Odds Ratio (95% CI)
 
1.01 (0.99–1.03)

1.00 (0.99–1.01)

1.02 (1.01–1.03)

Matched Analysis^{b}

IL6 as the Outcome

78 (39:39)
   
MPD
 
1.11

9.13

50.44

Pvalue
 
0.475

0.123

0.005

(b) Matched Analysis Using Observed IL6 vs. Unmatched Analysis Using Simulated IL6

Unmatched Analysis

Simulated IL6^{c}

192 (49:143)
   
Beta (SE)
 
0.0385 (0.0322)

0.00323 (0.002)

0.0176 (0.004)

Pvalue
 
0.231

0.105

0.0001

Odds Ratio (95% CI)
 
0.96 (0.90–1.03)

1.00 (0.99–1.01)

1.02 (1.01–1.03)

Matched Analysis

Observed IL6^{d}

78 (39:39)
   
Beta (SE)
 
0.00745 (0.0112)

0.00321 (0.00327)

0.0154 (0.0054)

Pvalue
 
0.508

0.326

0.005

Odds Ratio (95% CI)
 
1.01 (0.99–1.03)

1.00 (0.99–1.01)

1.02 (1.01–1.03)


^{a}The coefficients (Beta and SE), pvalues, and odds ratios came from the conditional logistic regression where delirium case was the outcome, and IL6 the independent variable

^{b}The MPD (median paired differences) is the median of the paired differences (concentration level of IL6 from the delirium case minus that of the control) within each time period. The pvalues came from the nonparametric signed rank test

PREOP preoperative, PACU postanesthesia care unit, POD2 postoperative day 2, SE standard error, CI confidence interval

^{c}The coefficients (Beta, SE), pvalues, and odds ratios came from the unconditional multivariable logistic regression with delirium case as the outcome, and the six match factors as independent variables

^{d}The coefficients (Beta, SE), pvalues, and odds ratios came from the conditional logistic regression where delirium case is the dependent variable, and IL6 the independent variable

PREOP preoperative, PACU postanesthesia care unit, POD2 postoperative day 2, SE standard error, CI confidence interval