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Table 2 Characteristics of randomized controlled trials

From: Trends in the number and the quality of trial protocols involving children submitted to a French Institutional Review Board

Characteristics of RCTs n = 50 2003–2008 (6 y) n = 27 2009–2014 (6 y) n = 23  
Total n (%) Drug 20 (74) Non drug 7 (26) Drug 20 (87) Non drug 3 (13)
Experimental design
 Parallel 43 (86) 19 5 17 2 0.697
 Cross-over 7 (14) 1 2 3 1  
Level of blind
 Double blind 29 (58) 13 1 14 1 0.052
 Single blind 2 (4) 1 0 0 1  
 Open labeled 19 (38) 6 6 6 1  
Allocation concealment
 Inadequate 4 (8) 2 0 2 0 0.055
 Unclear 20 (40) 7 6 5 2  
 Adequate 26 (52) 11 1 13 1  
Jadad class
 Median [interquartile range]   4 [3–5] 1 [1–2] 5 [2.5–5] 3 [1–5] 0.758
 Low quality <3 15 (30) 3 6 5 1  
 High quality ≥3 35 (70) 17 1 15 2  
Jadad class in sensitivity analysis
 Median [interquartile range]   5 [3–5] 3 [1–5] 5 [4–5] 5 [5–5] 0.650
 Low quality <3 5 (15) 2 1 2 0  
 High quality ≥3 28 (25) 13 1 12 2  
  1. Data are n (%) of RCTs and median [1st quartile – 3rd quartile] of Jadad score
  2. The p value corresponds to the comparison of the two periods for each listed variable including both “drug” and “non drug” RCTs