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Table 6 Estimations of fixed effect parameters (β p ) p=1,2,3 of the (cumulative,logistic, Z 1,U 2 ) model

From: Item response models for the longitudinal analysis of health-related quality of life in cancer clinical trials

HRQoL    
Dimensions Coefficient Standard error P-value
Global Health Status    
  β 2 0.098 0.070 0.166
  β 3 0.130 0.085 0.128
Physical functioning    
  β 2 -0.150 0.077 0.051
  β 3 0.122 0.098 0.212
Role functioning    
  β 2 -0.011 0.081 0.892
  β 3 0.157 0.103 0.131
Emotional functioning    
  β 2 0.335 0.070 <.001∗∗∗
  β 3 0.001 0.086 0.992
Cognitive functioning    
  β 2 -0.002 0.054 0.972
  β 3 0.088 0.067 0.189
Social functioning    
  β 2 0.010 0.073 0.888
  β 3 0.116 0.093 0.211
Fatigue    
  β 2 -0.087 0.085 0.308
  β 3 -0.033 0.107 0.761
Nausea and vomiting    
  β 2 -0.052 0.060 0.393
  β 3 -0.069 0.072 0.336
Pain    
  β 2 -0.330 0.076 <.001∗∗∗
  β 3 -0.188 0.092 0.040 ∗
Dyspnea    
  β 2 -0.060 0.075 0.420
  β 3 -0.093 0.088 0.295
Insomnia    
  β 2 -0.359 0.080 <.001∗∗∗
  β 3 0.046 0.083 0.627
Appetite loss    
  β 2 -0.354 0.072 <.001∗∗∗
  β 3 -0.026 0.080 0.747
Constipation    
  β 2 -0.325 0.077 <.001∗∗∗
  β 3 0.003 0.083 0.974
Diarrhea    
  β 1 0.739 0.272 0.007 ∗∗
  β 2 0.018 0.067 0.792
  β 3 -0.026 0.076 0.786
Financial difficulties    
  β 2 -0.522 0.282 0.066
  β 3 0.302 0.208 0.146
  1. All HRQoL dimensions of the EORTC QLQ-C30 are considered
  2. *P-value <.05; **P-value <.01; ***P-value <.001
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