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Table 1 Parameters of marginal true effect for the 15 simulated sub-cases

From: Performance of the marginal structural cox model for estimating individual and joined effects of treatments given in combination

Situations Case 1
α1 = 0.004, ω1 = 0.004
Strong confounding for A2
Case 2
α1 = 0.004, ω1 = 0.001
Weak confounding for A2
Case 3
α1 = 0.004, ω1 = 0.000
No confounding for A2
A β1 = 0.5, β2 = 0.5, β3 = 0 β1 = 0.5, β2 = 0.5, β3 = 0 β1 = 0.5, β2 = 0.5, β3 = 0
B β1 = 0.5, β2 = 0.5, β3 = 0.5 β1 = 0.5, β2 = 0.5, β3 = 0.5 β1 = 0.5, β2 = 0.5, β3 = 0.5
C β1 = 0, β2 = 0.5, β3 = 0 β1 = 0, β2 = 0.5, β3 = 0 β1 = 0, β2 = 0.5, β3 = 0
D β1 = 0, β2 = 0, β3 = 0.5 β1 = 0, β2 = 0, β3 = 0.5 β1 = 0, β2 = 0, β3 = 0.5
E β1 = 0, β2 = 0, β3 = 0 β1 = 0, β2 = 0, β3 = 0 β1 = 0, β2 = 0, β3 = 0
  1. α1 and ω1 are the coefficients of the time-dependent confounder in the functions of prediction for treatment A1 and A2, respectively