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Table 2 Comparison of estimates of HR for ARV obtained by Cox-MSM and standard time-dependent Cox models

From: Performance of the marginal structural cox model for estimating individual and joined effects of treatments given in combination

  aWeighted model with interaction Weighted model without interaction Time dependent Cox model with interaction
Covariates Hazard ratio 95% CI P value Hazard ratio 95% CI P value Hazard ratio 95% CI P value
PI alone vs no treatment 3.99 1.55–10.3 0.004 1.15 0.76–1.74 0.52 3.79 1.53–9.43 0.004
Other ARV alone vs no treatment 1.77 0.91–3.42 0.09 1.15 0.68–1.97 0.60 1.92 1.02–3.61 0.04
PI and Other ARV vs no treatment 1.69 0.84–3.39 0.14 1.32 0.76–2.31 0.33 1.90 1.00–3.68 0.05
  1. Hazard ratios for the causal effects of ARV combinations with and w/o PI versus no treatment on the risk of anal cancer in HIV-infected persons followed for 6,381,871 person-months
  2. aReference method
  3. Bold data indicate that the test was statistically significant