BMC Medical Research Methodology

Table 2 Overall and treatment strategy-specific subgroup definitions, sample sizes, and number of events for the case study

From: Accounting for parameter uncertainty in the definition of parametric distributions used to describe individual patient variation in health economic models

	Sample size	Event observations
	Sample size	Progression (Post-induction)	Death (Post-induction)	Progression (Re-induction)	Death (Re-induction)	Death (Salvage)
Subgroup 0: No Subgroups	558	519	39	370	109	410
Observation	279	270	9	200	54	216
Maintenance	279	249	30	170	55	194
Subgroup 1: SD	191	185	6	128	43	142
Observation	95	95	0	68	22	73
Maintenance	96	90	6	60	21	69
Subgroup 2: CR/PR	367	334	33	242	66	268
Observation	184	175	9	132	32	143
Maintenance	183	159	24	110	34	125
Subgroup 3: Synchronous	410	382	28	275	82	300
Observation	191	186	5	143	33	153
Maintenance	219	196	23	132	49	147
Subgroup 4: Metachronous	147	137	10	95	27	110
Observation	88	84	4	57	21	63
Maintenance	59	53	6	38	6	47
Subgroup 5: SD & Synchronous	141	136	5	94	34	102
Observation	67	67	0	49	15	52
Maintenance	74	69	5	45	19	50
Subgroup 6: SD & Metachronous	50	49	1	34	9	40
Observation	28	28	0	19	7	21
Maintenance	22	21	1	15	2	19
Subgroup 7: CR/PR & Synchronous	269	246	23	181	48	198
Observation	124	119	5	94	18	101
Maintenance	145	127	18	87	30	97
Subgroup 8: CR/PR & Metachronous	97	88	9	61	18	70
Observation	60	56	4	38	14	42
Maintenance	37	32	5	23	4	28

SD stable disease, CR/PR complete or partial response

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ISSN: 1471-2288

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