Skip to main content

Advertisement

Table 2 Estimated trial effectiveness, uptake and population impact of four interventions to decrease antibiotic prescription or consumption for acute respiratory infections in primary care

From: What’s the uptake? Pragmatic RCTs may be used to estimate uptake, and thereby population impact of interventions, but better reporting of trial recruitment processes is needed

  Trial effectiveness Uptake of intervention Population impact
Intervention Total event rate in intervention group Total event rate in control group Summary Relative Risk (95% CI) Relative Risk Reduction (RRR;1-RR) Total number of participating GPs Total number of potential participating GPs Population Uptake
(95% CI)
Relative risk reduction
(RRR × Uptake)
Ranking
Delayed prescribing 255/817 790/847 0.36 (0.27–0.48) 64% 48 255d 19% (14–24%) 12.0% 1
Procalcitonin 117/507 320/501 0.39 (0.17–0.86) 61% 53 345 15% (12–19%) 9.4% 2
CRP 631/1685 785/1599 0.78 (0.66–0.92) 22% 35 125 28% (20% – 36%) 6.2% 3
Shared decision making 5236a 4936a 0.61 (0.55–0.68) 39% 281b 3389b 9.5% (0–20%)c 3.7% 4
  1. aNumber of events not reported
  2. bTotal across 3 RCTs, combined in a logistic regression model with random intercepts
  3. cLower CI set as ≥0
  4. d22/61 practices participated; out of participating practices 48/92 GPs participated; therefore number of potential participating GPs is 92 × (61/22) = 255